CDK12与肿瘤相关性的研究进展  

Progress in the relevance of CDK12 with tumors

作　　者：汪浩[1] 王丽丽[1] 李鑫[1] 侯定坤[1] 徐子寒 董世强 王海涛[1] WANG Hao;WANG Lili;LI Xin;HOU Dingkun;XU Zihan;DONG Shiqiang;WANG Haitao(Department of Oncology,Second Hospital of Tianjin Medical University,Tianjin Institute of Urology,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院肿瘤科,天津市泌尿外科研究所,天津300211

出　　处：《肿瘤》2018年第7期711-715,共5页Tumor

基　　金：国家自然科学基金资助项目(编号：81572543)

摘　　要：恶性肿瘤一般表现为细胞分裂不受控制的病理过程。细胞周期蛋白依赖性激酶(cyclin-dependent kinases,CDKs)是一类调节细胞周期进程和基因转录过程的关键因子。CDKs的功能失调能够驱动肿瘤的发生,因此常被检测用来指导恶性肿瘤的治疗。CDK12是一种参与包括DNA损伤修复、细胞生长和分化、前体m RNA剪接和处理加工等多种细胞进程的转录相关性激酶。近期研究发现,多种肿瘤中存在着CDK12基因突变和扩增现象,如在高级别浆液性卵巢癌中CDK12基因发生功能缺失性突变,提示CDK 12可能是一种抑癌基因。然而,CDK12在某些肿瘤中过表达,表明CDK12还可能具有一些癌基因的特性。本文就CDK 12基因的结构、功能以及与恶性肿瘤的关系等最新研究进展进行综述。Cancer represents a pathological characteristic of uncontrolled cell division. The cyclin-dependent kinases（CDKs） are a kinds of key factors regulating cell cycle progression and transcription process. Since the dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested extensively as the targets for cancer therapy. CDK12 is a transcription-associated kinase which participates in various cellular processes, including DNA damage response, cellular development and differentiation, as well as precursor m RNA splicing and processing. The mutations and amplification of CDK12 gene have been recently reported in different types of malignancies, such as loss-of-function mutations in high-grade serous ovarian carcinomas, which suggests that CDK12 is a tumor suppressor. On the contrary, CDK12 is overexpressed in other tumors, which suggests that CDK12 has some properties of oncogene. This paper reviews the structure and function of CDK 12 gene, as well as the relationship between CDK12 gene and cancers.

关 键 词：肿瘤 细胞周期蛋白依赖激酶类 DNA修复 细胞周期 CDK12基因 

分 类 号：R730.2[医药卫生—肿瘤]