肺癌患者肺叶切除术围手术期雾化吸入痰热清的效果观察  

Effects of aerosol inhalation of Tanreqing during perioperative period of patients with lung cancer treated with pulmonary lobectomy

作　　者：傅淑琼[1] Fu Shuqiong(Department of General Practice,West China Hospital of Sichuan University,Chengdu,Sichuan,610041,China)

机构地区：[1]四川大学华西医院全科医学科,成都610041

出　　处：《西南国防医药》2018年第6期547-550,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探究肺癌患者肺叶切除术围手术期雾化吸入痰热清的效果。方法将124例行肺叶切除术的肺癌患者随机分为对照组和治疗组,均给予围手术期常规雾化治疗,治疗组加用痰热清雾化吸入。比较两组术前2 w、术前1 d和术后2 w的肺功能、动脉血气分析,治疗前后痰上清炎症因子水平,术后排痰和并发症情况。结果与术前2 w比较,两组Vf术前1 d先降低,术后2 w后升高;而FVC、FEV1和MVV则先升高后降低,但治疗组均大于同时点对照组(P<0.05);两组围手术期SpO_2、对照组围手术期PaO_2和PaCO_2均无显著变化(P>0.05);治疗组PaO_2术前1 d先升高,术后2 w后降低,而PaCO_2则先降低后恢复(P<0.05),且治疗组PaO_2高于对照组,PaCO_2则低于对照组(P<0.05);治疗后,两组白介素-6和白介素-8显著降低(P<0.05),且治疗组降低幅度大于对照组(P<0.05);治疗组术后有效排痰率为96.77%,并发症发生率为11.29%,对照组分别为77.42%,30.65%,差异均显著(P<0.05)。结论对接受肺叶切除术的肺癌患者,围手术期进行雾化吸入痰热清治疗,可显著改善患者肺功能,维持动脉血气指标稳定,降低肺内炎症反应和术后并发症。Objective To explore the effects of aerosol inhalation of Tanreqing during the perioperative period of the patients with lung cancer treated with pulmonary lobectomy. MeAods A total of 124 patients with lung cancer treated with pulmonar lobectomy were randomly and equally divided into a control group and a treatment group. The two groups were treated with routine atomization, and on the basis of this, the treatment group was additionally treated with aerosol inhalation of Tanreqing. The pulmonary function and arterial blood gas analysis two weeks and one day before the operation and two weeks after the operation, the levels of inflammatory cytokines in phlegm before and after the treatment, and the postoperative expectoration drainage and incidence of complications between the two groups were compared. Results Compared with that two weeks before the operation,the Vf in the two groups decreased one day before the operation and increased two weeks after the operation; FVC, FEV1 and MVV increased initially and decreased later, but the levels in the treatment group were higher than those in the control group at the same time point （P〈0.05）; the perioperative SpO2 between the two groups and the perioperative PaO2 and PaCO2 in the control group had no significant change （P〉0.05）; the PaO2 in the treatment group increased one day before the operation and decreased two weeks after the operation, while the PaCO2 decreased initially and restored later （P〈0.05）; the PaO2 in the treatment group was higher than that in the control group and the PaCO2 was lower than that in the control group （P〈0.05）; after the treatment, the interleukin-6 （IL-6） and interleukin-8 （IL-8） in the two groups decreased significantly （P〈0.05）, and the decrease in the treatment group was greater than that in the control group （P〈0.05）; the effective drainage rate after the operation in the treatment group was 96.77%, the incidence of complications was 11.29%, and those in the control gr

关 键 词：痰热清 雾化吸入 肺叶切除术 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]