Podoplanin及血管内皮生长因子受体-3在结直肠癌中表达的研究  

Expression of VEGFR-3 and podoplanin in colorectal carcinoma

作　　者：朱宝成 周彩芳 彭志勇 ZHU Bao-cheng;ZHOU Cai-fang;PENG Zhi-yong(Department of General Surgery,Qingpu Branch of Zhongshan Hospital in Fudan University,Shanghai 200000,Chin)

机构地区：[1]复旦大学附属中山医院青浦分院普外科,上海201700

出　　处：《哈尔滨医科大学学报》2018年第2期142-144,共3页Journal of Harbin Medical University

摘　　要：目的观察血管内皮生长因子受体-3(vascular endothelial growth factor receptor-3,VEGFR-3)及肾小球足突细胞膜黏蛋白(podoplanin)在结直肠癌手术组织中的表达,研究VEGFR-3及podoplanin在结直肠癌复发中的作用。方法应用免疫组织化学法检测30例结直肠癌手术组织和30例正常对照组织中VEGFR-3及podoplanin的表达。结果 VEGFR-3主要表达在直、结肠癌组织中,阳性表达率52. 5%,高于正常大肠组织中的阳性表达率,差异显著(P均<0. 05); podoplanin主要表达在细胞淋巴管内皮细胞上,podoplanin标记的淋巴管密度(LMVD)在直、结肠癌组织中表达高于正常大肠组织中的表达,差异显著(P均<0. 05)。结论 VEGFR-3及podoplanin在直、结肠癌中高表达。Objective To observe the expression of vascular endothelial growth factor receptor- 3 （ VEGFR-3 ） and podoplanin in colorectal carcinoma, and the role of VEGFR-3, podoplanin in colorectal carcinoma. Methods The expressions of VEGFR-3 and podoplanin in specimens of colorectal carcinoma and colorectal normal tissues were detected by immunohistochemistry. Results VEGFR-3 was mainly expressed in colorectal carcinoma, the positive rate was 52. 5% which was significantly higher than that of the normal bowel tissues （P 〈 0. 05 ）. The lymphatic vessel density （LMVD） marked by podoplanin of colorectal carcinoma were signifi- cantly higher than those of the normal bowel tissues （P 〈 0.05 ）. Conclusion VEGFR-3 and podoplanin express high specificity in coloreetal carcinoma.

关 键 词：结直肠癌 血管内皮生长因子受体-3 肾小球足突细胞膜黏蛋白 

分 类 号：R735.3[医药卫生—肿瘤]