轻型地中海贫血孕妇的铁代谢状况研究  

Iron metabolism in pregnant women with thalassemia minor

作　　者：邱婷 尹春艳[2] QIU Ting;YIN Chun-yan(Department of Gynecology and Obstetrics,Guangzhou Women and Children＇s Medical Center,Guangdong Guangzhou 510623,China;Department of Obstetrics,Guangdong Second People＇s Hospital,Guangdong Guangzhou 510317,China)

机构地区：[1]广州市妇女儿童医疗中心妇产科 [2]广东省第二人民医院产科

出　　处：《中国妇幼健康研究》2018年第7期853-856,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨轻型地中海贫血(地贫)孕妇妊娠中、晚期铁负荷水平。方法随机选取2015年12月至2016年12月在广东省第二人民医院定期产检的孕妇,妊娠中期轻型地贫组30例,贫血组19例,对照组19例;妊娠晚期轻型地贫组44例,贫血组46例,对照组28例。对所有病例检测血红蛋白(Hb)、血清铁蛋白(SF)、血清转铁蛋白受体(sTfR),并对数据进行分析。结果 (1)Hb:地贫组低于同期对照组,高于同期贫血组,妊娠中期组间比较差异有统计学意义(F=27.78,P<0.05),妊娠晚期组间比较差异有统计学意义(F=59.08,P<0.05);(2)SF:同期地贫组与对照组比较差异无统计学意义(P>0.05);(3)sTfR:地贫组高于同期对照组(F=16.26,P<0.05),与同期贫血组比较差异无统计学意义(P>0.05);(4)α地贫孕妇Hb高于同期β地贫孕妇,妊娠中期组间比较差异有统计学意义(t=2.45,P<0.05),妊娠晚期组间比较差异有统计学意义(t=2.15,P<0.05)。结论 (1)妊娠中、晚期轻型地贫孕妇并无铁负荷过重,在监测铁水平情况下,对合并缺铁的轻型地贫孕妇,适当补铁是合理且安全的;(2)在妊娠中、晚期,β地贫孕妇Hb水平均低于α地贫者,因此应更加重视检查β地贫孕妇的贫血程度;(3)sTfR用于鉴别轻型地贫与缺铁性贫血需进一步探讨。Objective To study the iron storage status of pregnant women with thalassemia minor during the second and third trimester.Methods Pregnant women undergoing regular prenatal care in Guangdong Second People＇s Hospital were selected randomly and divided into thalassemia minor in second trimester group（30 cases）,anemia in second trimester group（19 cases）,normal control group in second trimester（19 cases）,and thalassemia minor in third trimester group（44 cases）,anemia in third trimester group（46 cases）,normal control group in third trimester（28 cases）.Hemoglobin（Hb）,serum ferritin（SF）,and serum transferring receptor（sTfR）were detected and analyzed in all cases.Results Hb level in thalassemia minor group was lower than that in control group but higher than that in anemia group,and differences in both second trimester groups（F=27.78,P〈0.05）and third trimester groups（F=59.08,P〈0.05）were significant.Differences in SF levels in thalassemia minor group and control group of same gestational period had no statistical significance（P〉0.05）.Level of sTfR in thalassemia minor group was higher than that in normal group of same trimester（F=16.26,P〈0.05）,but no significant difference was observed by comparing sTfR in thalassemia group and anemia group of same trimester（P〉0.05）.Hb in pregnant women withα-thalassemia was significantly higher than that in pregnant women withβ-thalassemia,and differences was statistically significant both in groups of second trimester（t=2.45,P〈0.05）and groups of third trimester（t=2.15,P〈0.05）.Conclusions Thalassemia minor gravidas are not affected by iron overload neither in second nor third trimesters.It is safe and reasonable to intake iron supplement for thalassemia minor gravidas complaining of iron deficiency under monitoring of iron level.Hb inβ-thalassemia is lower than that inα-thalassemia in second and third trimesters.Therefore,it is important to monitor anemia degree inβ-thalassemia gravidas.Further study is

关 键 词：轻型地中海贫血孕妇 血红蛋白 血清铁蛋白 血清转铁蛋白受体 铁代谢 

分 类 号：R153.1[医药卫生—营养与食品卫生学]