子痫前期与儿童自闭症发生风险相关性Meta分析  

Preeclampsia and risk of children with autism spectrum disorder:A meta-analysis

作　　者：陈剑虹 谢璧蔚[3] 徐若霆 罗婉君[4] 卢敏贞 杨铱琳[4] 钟梅 黄启涛[2] CHEN Jian-hong;XIE Bi-wei;XU Ruo-ting;LUO Wan-jun;LU Min-zhen;YANG Yi-lin;ZHONG Mei;HUANG Qi-tao(Prenatal Diagnostic Center,Huizhou First Maternity and Child Healthcare Hospital,Guangdong Huizhou 516000,China;Department of Obstetrics and Gynecology,Nan fang Hospital,Southern Medical University,Guangdong Guangzhou 510515,China;First School of Clinical Medicine,Southern Medical University,Guangdong Guangzhou 510515,China;Second School of Clinical Medicine,Southern Medical University,Guangdong Guangzhou 510515,China)

机构地区：[1]广东省惠州市第一妇婴保健院产前诊断中心,广东惠州516000 [2]南方医科大学南方医院妇产科,广东广州510515 [3]南方医科大学第一临床医学院,广东广州510515 [4]南方医科大学第二临床医学院,广东广州510515

出　　处：《中国妇幼健康研究》2018年第7期868-874,共7页Chinese Journal of Woman and Child Health Research

基　　金：国家自然科学基金青年基金(81401208);广东省自然科学基金博士启动项目(2015A030310025);南方医院院长基金(2014B003)(2016B019);广东省医学科研基金(A2016524);大学生创新创业培训计划项目(201612121007;201712121152;201812121268)

摘　　要：目的评价孕妇发生子痫前期(preeclampsia),其儿童发生自闭症的风险,为临床应用提供证据。方法通过计算机检索PubMed、Embase、Cochrane database、Web of Science等数据库,查找相关研究,检索时限从建库至2016年9月。对纳入的文章进行质量评价,计算比值比(OR)及95%置信区间(CI),采用Stata 12.0软件进行Meta分析。结果纳入文献24篇,包括16篇病例对照研究和8篇队列研究。纳入自闭症儿童共计81 384例,同期正常儿童7 250 091例。Meta分析结果显示:与正常孕妇的儿童相比,子痫前期孕妇的儿童自闭症发生风险更高,差异有统计学意义(OR=1.44,95%CI:1.24~1.67,P<0.01)。结论孕妇发生子痫前期,其儿童发生自闭症的风险显著增加,评价孕妇子痫前期可能对于预测儿童自闭症发生风险有一定价值。Objective To evaluate the risk of maternal preeclampsia and children with outism spectrum disorder（ASD）so as to provide some evidence.Methods We conducted a systematic literature search in PubMed,Embase,Cochrane database and Web of Science to search related studies up to September 2016.Included literatures were evaluated.Odd ratio（OR）and 95% confidence interval（95% CI）were calculated,and statistical analysis was performed using Stata 12.0 software.Results Sixteen case-control studies and 8 cohort studies were recruited,involving 81 384 children with ASD and 7 250 091 non-autistic children at the same period.Meta-analysis results showed that the risk of incidence of children with ASD of mothers with preeclampsia was higher than that of normal pregnant women,and the difference was statistically significant（OR =1.44,95%CI：1.24-1.67,P〈0.01）.Conclusion The risk of children with ASD when mothers suffer from preeclampsia is significantly higher,and evaluating pregnant woman preeclampsia may has certain value in predicting risk of autism in children.

关 键 词：子痫前期 妊娠期高血压疾病 自闭症 META分析 

分 类 号：R74[医药卫生—神经病学与精神病学]