乳腺癌钼靶片钙化特征及其与HER2、VEGF表达的关系  

Calcification characteristics of molybdenum target and its relationship with HER2 and VEGF expression in breast cancer

作　　者：薛成伟[1] Xue Chengwei(Department of Radiology,Yan＇ an People＇ s Hospital,Yan ＇ an Shaanxi 716000,China)

机构地区：[1]延安市人民医院放射科,716000

出　　处：《中华普外科手术学杂志（电子版）》2018年第4期358-360,共3页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

摘　　要：目的探讨乳腺癌钼靶片钙化特征及其与HER2、VEGF表达的关系。方法回顾性分析2013年9月至2016年12月200例原发性乳腺癌钼靶片的钙化特点与HER2、VEGF表达的关系。采用统计学软件SPSS19.0进行分析,VEGF和HER-2阳性率用例(%)表示,采用χ2检验,并使用相关性检验,P<0.05差异具有统计学意义。结果对200例患者进行钙化特征和HER-2基因表达情况进行统计后发现,HER-2的过度表达与钙化、钙化+毛刺征、钙化数目>20枚、钙化簇最大径≥25 mm、蠕虫状钙化呈正相关,差异有统计学意义,P<0.05。统计研究对象钙化特点与VEGF过度表达之间的关系,发现VEGF过度表达与钙化呈负相关,P<0.05,差异有统计学意义。结论乳腺癌钼靶钙化特点与HER2、VEGF表达的关系密切,在临床上有利于乳腺癌的诊断及预后,有确切的临床意义。Objective To investigate the calcification characteristics of molybdenum target and its relationship with HER2 and VEGF expression in breast cancer. Methods The calcification characteristics of molybdenmn target in 200 cases of breast cancer treated in our hospital were analyzed. HER2 and VEGF were detected ＇after tumor resection. The relationship between calcification characteristics and the expression of HER2 and VEGF was analyzed. Results The results showed that the overexpression of HER2 was positively correlated with calcification, calcification ＋ burr, calcification number 〉 20, calcification cluster diameter ≥25 mm, worm-like calcification, and the difference was significant Statistically significant （P 〈 0.05 ）. Statistical study found that the overexpression of VEGF was negatively correlated with calcification （P 〈 0.05 ）, the difference was statistically significant. Conclusion The calcification of molybdenum target in breast cancer is closely related to the expression of HER2 and VEGF, which is of great clinical significance in the diagnosis and prognosis of breast cancer.

关 键 词：乳腺肿瘤 钙质沉着症 基因 ERBB-2 血管内皮生长因子类 

分 类 号：R730.44[医药卫生—肿瘤] R737.9[医药卫生—临床医学]