血清中期因子在肾癌患者外周血中的表达及其临床意义  

Expression and clinical significance of peripheral blood midkine in patients with renal carcinoma

作　　者：王腾春[1] 肖永双 温儒民 张冬梅 Wang Tengchun;Xiao Yongshuang;Wen Rumin(Department of Urology,the Second People Hospital of Liaocheng,Liaocheng 252600,China;Department of Urology,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China)

机构地区：[1]山东省聊城市第二人民医院泌尿外科,山东聊城252600 [2]徐州医科大学附属医院泌尿外科,江苏徐州221002 [3]徐州医科大学,江苏徐州221002

出　　处：《国际泌尿系统杂志》2018年第4期540-543,共4页International Journal of Urology and Nephrology

摘　　要：目的 检测肾癌（renal carcinoma,RCC）患者血清中期因子（midkine,MK）水平,探讨血清MK的测定在肾癌疾病诊断和预后判断方面的价值.方法 以2016年6月至12月就诊于徐州医科大学附属医院的63例原发肾癌患者为研究组,45例肾良性病变（肾结石、肾囊肿）和30例健康体检者为对照组,收集临床资料,分别抽取肾癌患者术前、术后（第7天）静脉血和对照组静脉血,用ELISA方法检测各组外周血中MK水平.并进行统计学分析,比较研究不同组中MK的表达差异.结果 ①外周血MK值在健康体检组、肾良性病变组、肾癌组（术前）分别为（27.33±3.19） ng/L、（34.63±2.28） ng/L、（60.25±1.88） ng/L,肾癌组（术前）高于肾良性病变组高于健康体检组,差异具有统计学意义（P＜0.01）;②外周血MK值在肾癌组（术前）和肾癌组（术后）分别为（60.32±2.01） ng/L和（50.36±3.12） ng/L,肾癌组（术前）高于肾癌组（术后）,差异具有统计学意义（P＜0.01）;③肾癌分期与外周血MK值正相关,差异具有统计学意义（P＜0.01）.结论 ①血清MK在肾癌中表达较肾良性病变和健康体检者增高;②血清MK在肾癌（术前）高于肾癌（术后）;③肾癌分期与血清MK值正相关,MK的升高也预示着肾癌患者较差的预后,表明血清中MK可能成为诊治肾癌的有效生物学标记物.Objective To detect the serum levels of midkine （MK） in patients with renal carcinoma （RCC）,and to discuss the value of determination of MK in the aspects of diagnosis and the condition of the disease.Methods The survey was conducted in 63 patients with primary renal carcinoma and 45 cases of benign renal disease （kidney stones,kidney cysts） and 30 healthy persons selected in the hospital between February 2016 and August 2016.The patients were divided into two groups：research group （n =63） and control group （n =75）.By collecting the related clinical data,extrac the venous blood in patients with renal carcinoma preoperative and postoperative （seventh days） and control group.ELSIA technique was used to measure MK level in peripheral blood of each group so as to analyse the correlation and compare the difference of the expression of MK in different groups.Results ①Peripheral blood MK values in healthy control group,benign renal lesion group,renal carcinoma group （preoperative） were （27.33 ± 3.19） ng/L,（34.63 ± 2.28） ng/L,（60.25 ± 1.88） ng/L,renal cell carcinoma group （preoperative） higher than that of benign renal lesions were higher than those in healthy group,the difference was statistically significant （P 〈 0.01）.② Preoperative and postoperative peripheral blood MK value in renal cell carcinoma group were （60.32 ± 2.01）ng/L and （50.36 ±3.12）ng/L,renal cell carcinoma group （preoperative） higher than that of RCC group （postoperative）,the difference was statistically significant （P 〈0.01）.③Renal carcinoma stage was positively correlated with MK value in peripheral blood,and the difference was statistically significant （P 〈 0.01）.Conclusions ①The expression of serum MK in renal carcinoma is significantly higher than that of the benign renal diseases and healthy subjects.②The expression of serum MK in renal carcinoma （preoperative） is higher than that of renal carcinoma （postoperative）.③MK value increases with the

关 键 词：肾肿瘤 载体蛋白质类 

分 类 号：R737.11[医药卫生—肿瘤]