81例肝脾T细胞淋巴瘤患者的预后分析  

Analysis on the prognosis of 81 patients with hepatosplenic T cell lymphoma

作　　者：冯烨 陈湘磊 郑译 刘樵 陈海榅 蔡媛华 曹丽霞 潘莉莉 李扬 王少元[3] FENG Ye;CHEN Xianglei;ZHENG Yi;LIU Qiao;CHEN Haiwen;CAI Yuanhua;CAO Lixia;PAN Lili;LI Yang;WANG Shaoyuan(School of Clinical Medicine,Fujian Medical University,Fuzhou,350001,China;Fuzhou Children＇s Hospital in Fujian;Department of Hematology,Fujian Medical University Union Hospital,Fujian Institute of Hematological Diseases,Key Laboratory of Hematology in Fujian)

机构地区：[1]福建医科大学临床医学院,福州350001 [2]福建省福州市儿童医院 [3]福建医科大学附属协和医院血液科,福建省血液病研究所,福建省血液病学重点实验室

出　　处：《临床血液学杂志》2018年第4期517-522,共6页Journal of Clinical Hematology

基　　金：省卫计委联合攻关计划项目(No:WKJ2016-2-07);福建省血液医学中心建设项目资助(No:闽政办2017-4);国家及省重点临床专科建设项目

摘　　要：目的:基于SEER数据库分析肝脾T细胞淋巴瘤(HSTCL)患者的临床特点及预后相关因素,为临床上HSTCL患者预后的分析提供参考。方法:通过美国SEER*Stat软件搜集1997-2014年病理确诊为HSTCL的患者共81例。生存分析采用Kaplan-Meier法,Log-rank检验,多因素分析采用Cox比例风险模型。结果:应用Kaplan-Meier法进行单因素生存分析,年龄的P值<0.05,性别、种族、Ann Arbor分期、诊断年份、是否行原发部位手术治疗的P值均>0.05;将患者性别、年龄、种族、Ann Arbor分期、诊断年份、是否行原发部位手术治疗等因素纳入Cox多因素回归分析显示,年龄与HSTCL患者预后有相关性(HR=2.066,95%CI 1.011~4.221,P=0.047),性别、种族、Ann Arbor分期、诊断年份、是否行原发部位手术治疗均与预后无相关性。结论:年龄对于HSTCL患者有预测价值,性别、种族、Ann Arbor分期、诊断年份、是否行原发部位手术治疗等因素对HSTCL患者的预后预测均没有价值。Objective：We investigated the clinical features and prognostic factors of patients with hepatosplenic T cell lymphoma（HSTCL）in order to provide reference for HSTCL prognosis.Method：A total of 81 patients with HSTCL registered in SEER database between 1997 and 2014 were identified by SEER＊Stat software.Survival analysis was performed by the Kaplan-Meier method and tested by the log-rank test.Multivariate analysis was studied by the Cox proportional hazard regression method after adjustment for significant covariates.Result：Univariate survival analysis carried out by Kaplan-Meier method showed the Pvalue of age was less than 0.05,while the Pvalues of sex,race,Ann Arbor stage,year of diagnosis and surgical treatment of primary site were greater than 0.05.Above factors entered Cox multivariate regression analysis showed that age was correlated with prognosis of HSTCL patients（HR=2.066,95%CI 1.011 to 4.221,P=0.047）.There was no correlation between prognosis and sex,race,Ann Arbor stage,year of diagnosis and surgical treatment of primary site.Conclusion：Age has predictive value for HSTCL patients.Factors such as sex,race,Ann Arbor staging,diagnostic year and surgical treatment of primary site have no value in predicting the prognosis of HSTCL patients.

关 键 词：肝脾T细胞淋巴瘤 SEER数据库 预后 生存 

分 类 号：R733.4[医药卫生—肿瘤]