免疫印迹法检测血清幽门螺旋杆菌抗体在体检人群中的意义  

Clinical significance of detection of Helicobacter Pylori antibodies in healthy population by immunoblotting

作　　者：孔乐乐[1] 梁艳[1] 刘魏 张婷[1] 周琳[1] KONG Yuele;LIANG Yan;LIU Wei;ZHAN Ting;ZHOU Lin(Department of Laboratory Diagnostics,Changzheng Hospital Affiliated to theSecond Military Medical University,Shanghai 200003,Chin)

机构地区：[1]第二军医大学附属长征医院实验诊断科,上海200003

出　　处：《国际检验医学杂志》2018年第A01期57-60,共4页International Journal of Laboratory Medicine

摘　　要：目的 探讨体检人群中幽门螺旋杆菌抗体的阳性率及分布情况。 方法 收集2016年6月至2017年6月至该院进行健康体检人员9 967例，年龄13~95岁，采用免疫印迹法检测血清幽门螺旋杆菌抗体，分析HP亚型在不同性别及不同年龄组的分布情况。 结果 HP抗体总阳性率为41%，男性HP抗体阳性率低于女性，差异有统计学意义（ P 〈0.05）。大于50岁年龄组UreA，UreB,CagA和VacA抗体阳性率明显高于其他年龄组（ P 均〈0.05）。Ⅱ型HP感染率为24.8%，明显高于I型HP感染，差异有统计学意义（ P 〈0.01）。 结论 免疫印迹法用于体检人群HP感染的普查和分型具有重要的临床价值。Objective： To explore the positivity and distribution of Helicobacter Pylori（HP） antibodies in healthy population. Methods： A total of 9967 healthy cases covering the range from 13-95 years of age were collected from June,2016 to June,2017.HP subtypes were detected by immunoblotting and analysed in gourps of different sex and age. Results The positivity rate of HP antibodies was 41% and that of the male was significantly lower than the female（ P 〈0.05）.The positivity rate of UreA,UreB,CagA and VacA antibodies of group aged above 50 was significantly higher than those of any other group（ P 〈0.05）.Type Ⅱ HP infection rate was 24.8%,higher than that of type I（ P 〈0.01）. Conclusion： The detection and typing of HP antibodies by immunoblotting are of important clinical significance in healthy population.

关 键 词：幽门螺旋杆菌 健康人群 免疫印迹法 

分 类 号：R573.1[医药卫生—消化系统]