神经导管的物理引导因素  

Physical guidance cues of nerve conduits

作　　者：项泱 吴屹冰 魏鹏[1] 尹俊[2] 戴光立[1] Xiang Yang;Wu Yi-bing;Wei Peng;Yin Jun;Dai Guang-li(Ningbo First Hospital,Ningbo 315000,Zhejiang Province,China;Zhejiang University,Hangzhou 310000,Zhejiang Province,China)

机构地区：[1]宁波市第一医院,浙江省宁波市315000 [2]浙江大学,浙江省杭州市310000

出　　处：《中国组织工程研究》2018年第26期4235-4240,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金青年项目(11402056);宁波市第二批科技项目(2017A610215)~~

摘　　要：背景:组织工程神经导管目前被广泛应用于周围神经损伤修复中,在导管内添加不同物理引导因素,具有提高修复神经缺损的潜力。目的:从管壁物理性质和管内物理引导方式两方面,归纳总结组织工程神经导管物理引导因素的研究进展。方法:用计算机检索web of science、万方数据库1980至2017年间发表的文献,中、英文检索词分别为"组织工程,神经导管,周围神经,损伤,物理结构"和"tissue engineering,nerve conduit,peripheral nerve,injury,scaffold,topological cues"。结果与结论:早期周围神经损伤主要通过自体神经移植和异体神经移植进行修复,然而其存在的缺点无法避免。组织工程神经导管作为桥接神经两断端的支架,避免了自体神经移植和异体神经移植的缺点。相关实验在神经导管内添加物理引导因素,证实具有更好的促进神经再生效果。如果神经导管在物理引导因素的设计上达到最优的平衡,结合生物化学因素的引入,将达到最优的促进神经修复效果,未来可以作为周围神经损伤修复的首要选择。BACKGROUND： A tissue-engineered nerve conduit for peripheral nerve repair is a popular alternative to peripheral nerve repair recently. Adding various physical guidance cues result in better outcome of regeneration of defected nerve. OBJECTIVE： To conclude the physical guidance cues in two aspects, including conduit luminal wall property andintralluminal guidance structures. METHODS： We searched WanFang database and Web of Science database for relevant literature published from 1980 to 2017 using the keywords of “tissue engineering; nerve conduit; peripheral nerve; injury; scaffold; topological cues” in Chinese and English, respectively.RESULTS AND CONCLUSION： Autograft and allograft are two main methods for peripheral nerve repair, but both of them have some inescapable disadvantages. Tissue-engineered nerve conduit as a scaffold bridging the nerve gap overcomes the above-mentioned disadvantages. In relative experiments, the introduction of physical guidance cues to the nerve conduit is proved to improve nerve regeneration. If physical guidance cues within nerve conduit achieve an optimal balance, the tissue-engineered nerve conduit with the introduction of biochemical guidance cues will achieve optimal outcome in nerve regeneration, and thus it seems to be the first choice for peripheral nerve repair in the future.

关 键 词：神经材料 周围神经 损伤 神经导管 物理结构 国家自然科学基金 生物材料 

分 类 号：R318[医药卫生—生物医学工程]