NapsinA、p40在肺腺癌、鳞癌中的表达及其与能谱CT定量指标的相关性  

Correlation between Expression of Napsin A and p40 in Lung Adenocarcinoma and Squamous Cell Carcinoma with Quantitative Analysis of CT by Energy Spectral

作　　者：尹译惠 刘云 刘炳霞 王艺霖 李妮 王楠 任小璐 YINYihui;LIUYun;LIU Bingxia;WANGYilin;LI Ni;WANG Nan;REN Xiaolu(Ningxia Medical University,Yinchuan 750004;Department of Radiology,the General Hospitalof Ningxia Medical University,Cardio Cerebrovascular Disease Hospital,Yinchuan 750002)

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院心脑血管病医院放射科,银川750002

出　　处：《宁夏医科大学学报》2018年第4期429-433,438,共6页Journal of Ningxia Medical University

摘　　要：目的探讨肺腺癌及鳞癌中Napsin A、p40表达及其与能谱CT参数的相关性。方法选取我院2016年1月至2017年4月期间行能谱CT扫描并经病理确诊的非小细胞肺癌患者68例(腺癌组36例,鳞癌组32例)。利用能谱成像对两组病例进行多参数定量分析,测得其平扫病变的有效原子序数(Effective-z)、钙含量、增强病变的标准碘含量(NIC)、70ke V单能量下肿块的强化程度ΔCT及能谱曲线斜率(k),采用免疫组化PV二步法测定腺癌组及鳞癌组中Napsin A、p40的表达情况。结果肺腺癌组与肺鳞癌组的Effective-z、钙含量、NIC以及能谱曲线斜率差异均有统计学意义(P均<0.05),病灶在70ke V单能量下的强化程度两组间差异无统计学意义(P>0.05)。Napsin A、p40在肺腺癌与肺鳞癌中的表达差异有统计学意义(P<0.05)。Napsin A在肺腺癌组的表达阳性率为97.22%,其表达情况与能谱CT的Effective-z、钙含量、NIC、能谱曲线斜率均呈正相关(P均<0.05);p40在肺鳞癌组的表达阳性率为100%,其表达情况与能谱CT的Effective-z、NIC、能谱曲线斜率均呈正相关(P均<0.05);肺鳞癌组p40的表达与钙含量呈负相关(P<0.05)。结论能谱CT成像的多参数定量分析对术前肺腺癌与鳞癌的鉴别诊断具有重要价值,对预测肿瘤某些生物学行为方面具有潜在价值。Object ive To investigate the relationship between the Napsin A and p40 expression in lung adenocarcinoma and squamous carcinoma with its spectral CT parameters. Methods A total of 68 patients with non-small cell lung cancer diagnosed by spectral CT and pathology were selected from our hospital between January 2016 and April 2017 as the study subjects（adenocarcinoma Group 36 cases,squamous carcinoma Group 32 cases）. Spectral CT imaging quantitative parameter analysis were used on two groups of cases. The Effective atomic number（Effective-z） and calcium content of the lesions by CT plain scan、Normalized iodine concentrations（NIC）on contrast enhanced CT、enhancement degree of the masses under70 ke V monochromatic spectral CT（ΔCT）and spectral curve slope were measured by the multiparameter quantitative analysis of two groups of cases. Immunohistochemistry of PV two-step staining was performed to detect the expression of Napsin A and p40 in adenocarcinoma group and squamous carcinoma group.Results Effective-z,calcium content,NIC and the slope of energy spectrum in the lung adenocarcinoma group and the lung squamous cell carcinoma group were statistically significant（P〈0.05）. There was no significant difference between the two groups（P〉0.05）for the intensification of the foci under the single 70 ke V energy.The expression of Napsin A and p40 in lung adenocarcinoma and lung squamous cell carcinoma was significantly different（P〈0.05）. The positive rate of Napsin A in lung adenocarcinoma was 97.22%,and its expression was positively correlated with Effective-z,calcium content,NIC and the slope of energy spectrum of CT（P〈0.05）. The positive rate of p40 in lung squamous cell carcinoma was 100%,and its expression was positively correlatedwith Effective-z,NIC and the slope of the energy spectrum curve（P〈0.05）. The expression of P40 in the lung squamous cell carcinoma group was negatively correlated with the calcium content（P〈0.05）.Conclusion Multiparameter quantitative o

关 键 词：肺癌 体层摄影术 X线计算机扫描 NAPSIN A P40 

分 类 号：R734.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学]