The effect of operating conditions on acylation of 2-methylnaphthalene in a microchannel reactor  

作　　者：Wenpeng Li Suohe Yang Xiaoyan Guo Guangxiang He Haibo Jin 

机构地区：[1]Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology,College of Chemical Engineering,Beijing Institute of Petrochemical Technology

出　　处：《Chinese Journal of Chemical Engineering》2018年第6期1307-1311,共5页中国化学工程学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China(91634101);The Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges under Beijing Municipality(IDHT20180508)

摘　　要：Acylation of 2-methylnaphthalene(2-MN) is a very important reaction in organic synthesis,and the effiency of the continuous reactor is more than one of the batch reactor.Considering that the Friedel–Crafts acylation is a rapid exothermic reaction,in this study,we perform the acylation of 2-MN in a stainless steel microchannel flow reactor,which is characterized by high mass and heat transfer rates.The effect of reactant ratio,mixing temperature,reaction temperature,and reaction time on product yield and selectivity were investigated.Under the optimal conditions,2-methyl-6-propionylnaphthalene(2,6-MPN) was obtained in 85.8% yield with 87.5% selectivity.Compared with the conventional batch system,the continuous flow microchannel reactor provides a more efficient method for the synthesis of 2,6-MPN.Acylation of 2-methylnaphthalene（2-MN） is a very important reaction in organic synthesis,and the effiency of the continuous reactor is more than one of the batch reactor.Considering that the Friedel–Crafts acylation is a rapid exothermic reaction,in this study,we perform the acylation of 2-MN in a stainless steel microchannel flow reactor,which is characterized by high mass and heat transfer rates.The effect of reactant ratio,mixing temperature,reaction temperature,and reaction time on product yield and selectivity were investigated.Under the optimal conditions,2-methyl-6-propionylnaphthalene（2,6-MPN） was obtained in 85.8% yield with 87.5% selectivity.Compared with the conventional batch system,the continuous flow microchannel reactor provides a more efficient method for the synthesis of 2,6-MPN.

关 键 词：ACYLATION Microchannel reactor 2-METHYLNAPHTHALENE 2-Methyl-6-propionylnaphthalene 

分 类 号：O621.25[理学—有机化学]