5-氨基酮戊酸光动力治疗宫颈环状电切术后高危HPV感染的疗效评价  

Efficacy of topical photodynamic therapy with 5-aminolevulinic acid on treating high risk human papilloma virus infection after loop electrosurgical excision procedure

作　　者：孟宪敏[1] 石秀艳[1] 刘薇[1] 王红英[1] 王冲 马倩倩 栾红[1] MENG Xianmin;SHI Xiuyan;LIU Wei;WANG Hongying;WANG Chong;MA Qianqian;LUAN Hong(Department of Dermatology,Liaocheng People＇s Hospital and Clinical School of Taishan Medical University,Liaocheng 252000,Chin)

机构地区：[1]山东省聊城市人民医院,252000

出　　处：《中国麻风皮肤病杂志》2018年第7期411-413,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:评价5-氨基酮戊酸光动力治疗宫颈环状电切术后高危型人乳头瘤病毒(HR-HPV)感染的疗效。方法:收集我院2015年1月至2016年6月经宫颈环状电切术治疗的宫颈上皮内瘤变II级、术后6个月液基薄层细胞(TCT)检测无异常、HR-HPV检测持续阳性患者。随机分成治疗组和对照组,治疗选在非月经期,治疗组给予光动力治疗,每周1次,连续治疗3次;对照组,给予干扰素治疗,每日用药1次,每次用量为80万IU,每个月经周期使用10次,连续3个月。结果:共42例患者入选,治疗组(20例)和对照组(22例)12个月HR-HPV转阴率分别为80%和36%,差异有统计学意义(P<0.05)。结论:5-氨基酮戊酸光动力治疗宫颈环状电切术后高危HPV感染有效。Objective： To assess the efficacy of 5-aminolevulinic acid photodynamic therapy（ ALA-PDT）for treating high risk human papilloma virus（ HR-HPV） infection after loop electrosurgical excision procedure（ LEEP）. Methods： The patients with cervical intraepithelial neolasia II treated by loop electrosurgical excision procedure,with normal Thinprep Cytologic Test（ TCT） for 6 months and positivity for HR-HPV were selected from January 2015 to June 2016. The patients were divided into the treatment group and control group randomly. The patients in the treatment group were treated with 5-aminolevulinic acid photodynamic therapy（ ALA-PDT）,once a week,for 3 times. The patients in the control group were treated with interferon,800000 IU,once a day,10 times each menstrual cycle for 3 months. Results： Forty-two patients were collected.The HR-HPV negative conversion rates were 80% in the treatment group（ 20 patients） and 36% in the control group,with a significant difference（ P〈0.05）. Conclusion： ALA-PDT is effective in the treatment of HR-HPV after LEEP.

关 键 词：光动力 宫颈上皮内瘤变 宫颈环状电切术 高危人乳头瘤病毒 

分 类 号：R737.33[医药卫生—肿瘤]