β七叶皂甙钠与丹参注射液联合应用治疗胶质瘤术后脑水肿的效果分析及对氧化应激指标的影响  

Effect Analysis of β Aescinate Sodium and Salvia Miltiorrhiza Injection in the Treatment of Brain Edema after Glioma and Influence on Oxidative Stress

作　　者：苏飞[1] 佟建洲[1] 孙文栋[1] SU Fei;TONG Jianzhou;SUN Wendong(The First Central Hospital of Baoding City,Baoding 071000,China)

机构地区：[1]河北省保定市第一中心医院,河北保定071000

出　　处：《中国医学创新》2018年第17期1-5,共5页Medical Innovation of China

摘　　要：目的:探讨β七叶皂甙钠联合丹参注射液对脑胶质瘤手术后患者的神经保护作用及对氧化应激指标的影响。方法:选取2015年9月-2017年1月保定市第一中心医院神经外科诊治的脑胶质瘤患者102例,按照随机数字表法将患者分为治疗组与对照组,各51例。患者入院后均给予基础减压手术与常规药物对症治疗,在此基础上治疗组加用β七叶皂甙钠粉剂注射和丹参注射液治疗,两组疗程均为3个月,疗程结束后观察NIHSS评分改善情况,检测血清NSE与S-100B含量的变化,以及氧化应激指标(MDA、SOD)的影响,并详细记录不良反应。结果:疗程结束后,治疗组的总有效率为94.12%(48/51),与对照组的92.16%(47/51)比较,差异无统计学意义(P>0.05)。与治疗前比较,治疗后两组的NIHSS评分较治疗前均显著下降,且治疗组下降较对照组更显著(P<0.01)。与治疗前比较,治疗后两组患者血清NSE与S-100B含量均明显下降,差异均有统计学意义(P<0.05),且两组间上述指标比较,差异均有统计学意义(P<0.05)。治疗后两组患者氧化应激状态均有所好转,其中血清MDA水平显著下降,而SOD水平显著上升,与治疗前比较均有显著改善,且与对照组比较,治疗组上述两项指标改善更明显(P<0.05)。治疗后治疗组的活动能力、生理功能、生理职能与精神健康评分均明显高于对照组(P<0.05)。两组均未发生明显不良反应。结论:β七叶皂甙钠与丹参注射液联合应用能有效发挥脑神经保护作用,其作用机制可能与降低血清S-100B蛋白、NSE的水平及改善氧化应激水平有关。Objective：To investigate the neuroprotective effect of β Aescinate Sodium combined with Salvia Miltiorrhiza Injection on the patients with glioma and the effect on the oxidative stress.Method：From September 2015 to January 2017,102 glioma patients treated and treated by neurosurgery in the First Central Hospital of Baoding City were selected,according to the random digital table method,the patients were divided into treatment group and control group,51 cases in each group.After admission,patients were treated with basic decompression surgery and conventional drugs,on this basis,the treatment group was treated with β Aescinate Sodium and Salvia Miltiorrhiza Injection,the course of treatment in both groups were 3 months,the improvement of NIHSS score,the changes of serum NSE and S-100 B levels and the effect of oxidative stress index（MDA,SOD） were observed after the treatment,and the adverse reactions were recorded in detail.Result：After treatment,the total effective rate of the treatment group was 94.12%（48/51）,compared with 92.16%（47/51） of the control group,the difference was not statistically significant（P〈0.05）.Compared with before treatment,the NIHSS scores of the two groups after treatment were significantly lower than those before treatment,and the decrease of the treatment group was more significant than that of the control group（P〉0.01）.Compared with before treatment,the serum levels of NSE and S-100B decreased significantly in the two groups after treatment,and the differences were statistically significant（P〈0.05）,and the differences between the two groups were statistically significant（P〈0.05）.After treatment,the oxidative stress state of the two groups were improved,in which the serum MDA level was significantly decreased,while the SOD level was significantly increased,compared with the control group,the above two indexes in the treatment group were significantly improved（P〈0.05）.After treatment,the scores of activity,physiological function,physiologic

关 键 词：Β七叶皂甙钠 丹参注射液 脑胶质瘤 神经保护机制 S-100B蛋白 NSE 氧化应激 

分 类 号：R739.41[医药卫生—肿瘤]