纤维内仿生矿化机制研究进展  

Review of the mechanism of biomimetic intrafibrillar mineralization

作　　者：牛丽娜 陈吉华 焦凯 NIU Lina;CHEN Jihua;JIAO Kai(State Key Laboratory of Military Stomatology,National Clinical Research Center for Oral Diseases,Shaanxi Key Laboratory of Oral Diseases,Department of Prosthodontics,School of Stomatology,The Fourth Military Medical University,Xi＇an 710049,China)

机构地区：[1]军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病重点实验室,第四军医大学口腔医院修复科,陕西西安710049

出　　处：《口腔疾病防治》2018年第6期347-353,共7页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金优青项目(81722015);陕西省科技新星项目(2016KJXX-18)

摘　　要：天然骨组织是人体高度矿化的硬组织,主要由有机质(Ⅰ型胶原及非胶原蛋白)和纳米羟基磷灰石无机矿物以7级分级有序排列的方式相互作用而形成。纤维内矿化胶原是骨组织的基本结构单元,并成为其优异的机械学性能和生物学性能的纳米结构基础。因此,如何模拟骨组织的纤维内矿化模式并探明其形成机理是仿生矿化领域研究的热点问题。本文阐述近年来纤维内仿生矿化研究方面的进展,并就目前主流的纤维内仿生矿化机制进行分析,以期为高活性的人工骨再生修复材料的构建提供理论依据,为对生物矿化本质的揭示提供线索。Bone is a hierarchically structured and highly mineralized hard tissue composed of an organic phase（type I collagen and noncollagenous proteins） and an inorganic phase（nanohydroxyapatite）. Intrafibrillar mineralized col-lagen is the basic structural unit of bone tissue and is of high significance due to its superior mechanical and biologicalproperties. Thus, to truly understand the unique properties of bone, it is necessary to review the most basic structurallevel of bone. In this article, we review the recent advances in understanding the development of intrafibrillar mineral-ization and the prevailing theories in the formation of such intrafibrillar minerals. Understanding the mechanisms of in-trafibrillar mineralization may facilitate the development of engineered bone for clinical applications and provide deeperinsight into the nature of biomineralization.

关 键 词：仿生矿化 非胶原蛋白 纤维内矿化 无定形磷酸钙 成核前体 

分 类 号：R783.4[医药卫生—口腔医学]