糖预处理对胃肠道肿瘤患者术后胰岛素和C肽水平的比较研究  

Comparative study of the pretreatment glucose for levels of postoperative insulin and C-peptide of patients with gastroenteric tumor

作　　者：任瑞锋[1] 彭艳军 罗英[1] 申菲 彭克楠 马顺茂[1] REN Rui-feng;PENG Yan-jun;LUO Ying(Department of Nuclear Medicine,North China Petroleum Administration Bureau General Hospital,Renqiu 062552,China)

机构地区：[1]华北石油管理局总医院核医学科,河北任丘062552 [2]河北省人民医院检验科,河北石家庄050057

出　　处：《中国医学装备》2018年第6期108-110,共3页China Medical Equipment

基　　金：中国石油华北油田临床医学研究项目(2013-HG-G-19-1)"糖预处理对消化道肿瘤术后胰岛素抵抗及炎性反应的研究"

摘　　要：目的:探讨糖预处理对胃肠道肿瘤手术后血清胰岛素和C肽水平的影响。方法:选取60例胃肠道肿瘤择期手术患者,采用数字表分法随机将其分为治疗组和对照组,每组30例。治疗组患者术前给予糖预处理,即麻醉前2 h口服含50 g葡萄糖的碳水化合物300 ml;对照组患者按传统方法进行,术前12 h禁食,术前6 h禁饮。分别于术前3 h、术后1 d、3 d和7 d抽取两组患者外周血,监测空腹血糖(FBG)、空腹胰岛素(FINS)定量,空腹C肽(C-P)定量。结果:术后第1 d、3 d对照组FBG和CP水平明显高于治疗组,两组比较差异有统计学意义(t=5.565,t=3.318;P<0.05);术后第7 d治疗组FBG、FINS及CP水平接近术前,而对照组术后第1 d、3 d和7 d的FINS水平高于治疗组,差异有统计学意义(t=4.700,t=4.374,t=4.347;P<0.05。结论:胃肠肿瘤患者术前给予糖预处理,对于胃肠肿瘤手术后胰岛素和C肽水平能够产生影响,可缩短胃肠道肿瘤手术后胰岛素抵抗的时间。Objective： To investigate the effects of pretreatment glucose for levels of postoperative insulin and C-peptide of patients with gastroenteric tumor. Methods： 60 patients with gastroenteric tumor who were in term of selective operation were divided into treatment group（n=30） and control group（n=30） as random number method. Patients of treatment group received pretreatment glucose（took orally 300 m L carbohydrate contained 50 g glucose at 2 hours preanesthetization）, and ones of control group received conventional method（fasting 12 hours pre-operation, and waterdeprivation 6 hours pre-operation）. The peripheral blood of patients were blooded at 3 hours pre-operation, 1 day postoperation, 3 days post-operation and 7 days post-operation so as to monitor fasting blood-glucose（FBG）, quantity of fasting insulin（FINS） and quantity of fasting C-peptide（C-P）. Results： At the post operation 1 day and 3 days, the levels of FBG and CP of control group were significantly higher than that of treatment group（t=5.565, t=3.318, P〈0.05）, and the levels of FBG, FINS and CP post operation 7 days were closed to preoperative levels of treatment group, respectively. While the levels of FINS post operation 1 day, 3 days and 7 days of control group were significantly higher than that of treatment group（t=4.700, t=4.374, t=4.347, P〈0.05）, respectively. Conclusion： The pretreatment of glucose for patients with gastroenteric tumor can affect the levels of postoperative insulin and C-P of patients, and shorten the time of post operation insulin resistance.

关 键 词：糖预处理 胃肠道肿瘤手术 胰岛素 C肽 胰岛素抵抗 

分 类 号：R735.2[医药卫生—肿瘤]