梗阻性结直肠癌预后影响因素及淋巴结转移度价值  

Influencing factors of prognosis of obstructive colorectal cancer and lymph node ratio values

作　　者：鲁全芝 LU Quanzhi(The Second People＇s Hospital of Jiaozuo, Jiaozuo Henan 454150, Chin)

机构地区：[1]焦作市第二人民医院,河南焦作454150

出　　处：《中国民康医学》2018年第10期79-81,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨梗阻性结直肠癌预后影响因素及淋巴结转移度(lymph Node Ratio,LNR)价值。方法:选取44例梗阻性结直肠癌患者为研究对象,回顾性分析其临床病理资料,将患者按LNR比值为0~0.24、0.25~0.49、0.5~0.74、0.75~1.0分成LNR 1、LNR 2、LNR 3和LNR 4四个亚组。COX模型分析包含LNR在内可能影响患者预后的相关因素,Kaplan-Meier生存曲线检验LNR不同亚组之间的总生存率(Overall survival,OS)。结果:COX回归分析显示,肿瘤分化程度、AJCC T分期、淋巴结检出数和LNR均与结直肠肿瘤患者的预后密切相关(P<0.05);LNR 1、LNR 2、LNR 3、LNR 4四个亚组5年OS分别为47.4%、27.3%、25.0%、16.7%,随着LNR值增高,患者5年OS逐渐下降,差异有统计学意义(P<0.05);淋巴结检出<12枚组的OS显著低于≥12枚组,差异有统计学意义(P<0.05)。结论:肿瘤分化程度、AJCC T分期、淋巴结检出数和LNR均是梗阻性结直肠癌患者预后的影响因素,降低患者LNR值有助于改善患者预后。Objective： To investigate influencing factors of prognosis of obstructive colorectal cancer and lymph node ratio values. Methods： The clinical and pathological data of 44 patients with obstructive colorectal cancer retrospectively analyzed. All these patients were divided into LNR1,LNR2,LNR3 and LNR4 subgroups according to the ratio of 0-0. 24,0. 25-0. 49,0. 5-0. 74 and0. 75-1. 0. COX model was used to analyze the factors that might affect the prognosis of patients,including LNR,and the Kaplan-Meier survival curve was used to examine the overall survival rate（ Overall survival,OS） among these LNR subgroups. Results： COX regression analysis showed that tumor differentiation,AJCC T staging,lymph node number,and LNR were significantly correlated with the prognosis of the colorectal cancer patients（ P〈0. 05）. The Kaplan-Meier curve further showed that with the increase of LNR,LNR1,LNR2,OS decreased,the 5-years OS of LNR1,LNR2,LNR3 and LNR4 subgroups were 47. 4%,27. 3%,25%,and16. 7%,there were significant differences among the four groups（ P〈0. 05）. The OS of the group with detected lymph node number 〈12 was significantly lower than that of the group with detected lymph node number ≥ 12,and the difference was statistically significant（ P〈0. 05）. Conclusions： Tumor differentiation,AJCC T staging,lymph node number,and LNR are the influencing factors of prognosis of the obstructive colorectal cancer patients,and decreased LNR is beneficial to improve the prognosis.

关 键 词：淋巴结 转移 预后 

分 类 号：R735.37[医药卫生—肿瘤]