胃癌患者T淋巴细胞亚群和白细胞相关参数的表达分析  

Expression of T lymphocyte subsets and white blood cell parameters in patients with gastric cancer

作　　者：郭欣[1] 时晓冬[2] 宫敬伟 郝冀洪[1] 王丽芳[1] 王燕[2] GUO Xin;SHI Xiao-dong;GONG Jing-wei;HAO Ji-hong;WANG Li-fang;WANG Yan(Department of Clinical Laboratory,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Department of Gastroenterology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Department of Medical Oncology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院检验科,河北石家庄050000 [2]河北医科大学第二医院消化科,河北石家庄050000 [3]河北医科大学第二医院肿瘤科,河北石家庄050000

出　　处：《河北医科大学学报》2018年第7期828-832,共5页Journal of Hebei Medical University

基　　金：河北省自然科学基金项目(H2014206117);河北省医学科学研究重点课题(20160526)

摘　　要：目的探讨T淋巴细胞亚群及血常规参数在胃癌患者中表达及变化。方法共纳入98例正常对照和126例晚期胃癌患者,应用流式细胞仪测定T淋巴细胞亚群,应用全自动血细胞分析仪检测血常规参数。结果病例组外周血CD3^+和CD4^+较对照组降低(P<0.05);2组CD8^+和CD4^+/CD8^+比值差异无统计学意义(P>0.05)。病例组治疗前外周血中白细胞计数、中性粒细胞计数、中性粒细胞/淋巴细胞比值高于对照组,淋巴细胞计数、血红蛋白低于对照组(P<0.05);病例组治疗后白细胞计数接近对照组(P>0.05),但是细胞构成比例有较大差异,中性粒细胞计数偏高,淋巴细胞计数偏低,中性粒细胞/淋巴细胞比值仍高,血红蛋白降低,血小板计数降低(P<0.05)。病例组治疗后与治疗前相比,外周血白细胞计数、中性粒细胞计数、中性粒细胞/淋巴细胞比值、血小板计数均降低(P<0.05)。结论晚期胃癌患者T淋巴细胞亚群平衡存在异常,CD3^+和CD4^+均明显降低,外周血中性粒细胞计数升高,淋巴细胞计数降低,中性粒细胞/淋巴细胞比值升高;测定患者T淋巴细胞亚群及中性粒细胞/淋巴细胞比值对于患者治疗及预后具有一定临床价值。Objective To investigate the expression and changes of T lymphocyte subsets and blood routine parameters of gastric cancer patients.Methods A total of 224 subjects were recruited and divided into two groups：98 controls and 126 gastric cancers, T lymphocyte subsets were measured by flow cytometry and blood routine test was measured by automatic analyzer.Results CD3 ＋T and CD4 ＋T lymphocytes were decreased significantly（ P 〈 0.05）, the ratio of CD4 ＋/CD8 ＋ was decreased slightly（ P 〉 0.05） and CD8 ＋T cells seemed did not change, the white blood cell count, neutrophil and neutrophil/lymphocyte ration of the case group were higher than the control group and lymphocyte, hemoglohin were lower（ P 〈 0.05）.Conclusion The balance of T lymphocyte subsets in patients with advanced gastric cancer was abnormal, while CD3 ＋ and CD4 ＋T lymphocytes were significantly decreased. Peripheral blood neutrophils increased, lymphocytes decreased, and neutrophil to lymphocyte ration increased. Determination of T lymphocyte subsets and neutrophil/lymphocyte ration in patients has certain clinical value for treatment and prognosis.

关 键 词：胃肿瘤 T淋巴细胞 白细胞 

分 类 号：R735.1[医药卫生—肿瘤]