二次电切联合注射用A群链球菌膀胱灌注治疗高级别浅表膀胱癌疗效  

Repeat Transurethral Resection of Bladder Tumor Resected With Streptococcus A Group For Injection Intravesical Instillation for the Treatment of Superficial Bladder Cancer

作　　者：蒙勇燕 陈光 MENG Yongyan;CHEN Guang(Department of Urology,Liuzhou Workers＇ Hospital,Liuzhou Guangxi 545000,China)

机构地区：[1]柳州市工人医院泌尿外科,广西柳州545000

出　　处：《中国继续医学教育》2018年第18期84-86,共3页China Continuing Medical Education

摘　　要：目的比较非肌层浸润性膀胱高级别尿路上皮癌二次经尿道膀胱肿瘤电切术(Re-TURBT)联合膀胱灌注注射用A群链球菌(沙培林)或表柔比星的疗效。方法 84例患者均行TURBT,术后诊断为非肌层浸润性膀胱高级别尿路上皮癌,均进行Re-TURBT,术后44例采用沙培林进行膀胱灌注治疗(试验组),40例采用表柔比星进行膀胱灌注治疗(对照组)。结果试验组和对照组均成功完成Re-TURBT。试验组膀胱癌术后复发率低于对照组,差异具有统计学意义(P<0.05)。结论 Re-TURBT联合膀胱灌注沙培林疗效优于表柔比星,是治疗非肌层浸润性膀胱高级别尿路上皮癌安全有效的方法。Objective To compare the curative effect of Re-TURBT resected with intravesical instillation of streptococcus A group for injection（sapirin） or epirubicin in non-muscle invasive bladder high grade urothelialcarcinoma. Methods TURBT was performed in all 84 patients, and nonmuscle invasive bladder high grade urothelial carcinoma was diagnosed after operation. All patients underwent Re-TURBT. 44 cases were treated with intravesical instillation of sapirin（experimental group）. 40 patients were treated with epirubicin for intravesical instillation（control group）. Results The experimental group and the control group were successfully completed the Re-TURBT. The recurrence rate of bladder cancer in experimental group was lower than that in control group, the difference was statistically significant（P〈0.05）. Conclusion Re-TURBT combined with perfusion of sapylin better than perfusion epirubicin, which is a safe and effective method for the treatment of non-mycositic invasive bladder high-grade urothelial carcinoma.

关 键 词：二次电切术 注射用A群链球菌 非肌层浸润性膀胱高级别尿路上皮癌 疗效 术后复发率 肿瘤 

分 类 号：R737[医药卫生—肿瘤]