透明质酸-阿魏酸靶向药物对Lewis肺癌荷瘤小鼠的抑制作用研究  

The Anti Tumor Effect of Ferulic Acid Decoreted Hyaluronic Acid on Spontaneous Lung Metastasis Model Mice of Lewis Lung Cancer

作　　者：赵玉玺[1] 魏莹[1] 陈珍[1] 张世鹏[1] 刘福 Zhao Yuxi, Wei Ying, Chen Zhen, Zhang Shipeng, Liu Fu(School of Pharmacy, Institute of medicine ,North Sichuan Medical University, Nanchong 637000, Chin)

机构地区：[1]川北医学院药学院药物研究所,四川南充637000

出　　处：《广东化工》2018年第13期30-31,共2页Guangdong Chemical Industry

摘　　要：目的:合成透明质酸-阿魏酸靶向药物并对其进行Lewis肺癌荷瘤小鼠的抑制作用研究。方法:使用丝氨酸甲酯作为中间连接物合成HA-FA靶向药物,采用紫外扫描图及1HNMR图谱进行结构确证;Bal b/c小鼠右腋皮下接种Lewis肺癌瘤株,连续腹腔注射给药20 d后,处死动物,摘取瘤体称重,并计算肿瘤生长抑制。结果:通过紫外扫描图可以初步证明HA-FA成功合成;1HNMR图谱进行结构确证。HA-FA对Lewis肺癌荷瘤小鼠的抑瘤率为57.97%(与模型组比较,P<0.05)。结论:HA-FA对Lewis肺癌荷瘤小鼠肿瘤生长具有明显抑制作用。Objects： To prepare hyaluronic acid targeted drug with ferulic acid and hyaluronic acid and to study the anti-tumor effect of HA-FA on Lewis lung cancer mice. Methods： Serine methyl ester was used as a linker to synthesis HA-FA targeted drugs. UV spectra and 1HNMR was used to identify its structure, Lewis lung cancer cells were inoculated subcutaneously into right axillary ofBal b/c mice, aiter continuous treatment of 20 d, we sacrificed the mice, removed tumor and weighed, and calculated the rate of tumor growth inhibition. Results： FA was successfully coupled with HA confirmed by UV spectra and IHNMR.HA-FA team inhibitory rates were 64.72 % （compared with the model group, P〈0.05）.Conclusions： HA-HA can inhibit significantly Lewis lung cancer tumor growth of the tumor-bearing mice.

关 键 词：透明质酸 靶向药物 阿魏酸 肿瘤 

分 类 号：TQ[化学工程]