表柔比星分别联合碘油与Hepasphere载药微球对肝癌患者TACE的疗效分析  

Efficacy of epirubicin combined with lipiodol or Hepasphere loaded microspheres in the treatment of TACE in patients with hepatocellular carcinoma

作　　者：池琦[1] 张玲玲[2] 刘彬 张国安[3] Chi Qi;Zhang Lingling;Liu Bin;Zhang Guoan(Department of Medical Imaging Intervention;Department of Neurology;Department of Medical Imaging,General Hospital of Fushun Mining Bureau,Liaoning Fushun 113000,China.)

机构地区：[1]抚顺矿务局总医院医学影像科介入病房,辽宁抚顺113000 [2]抚顺矿务局总医院,神经内科,辽宁抚顺113000 [3]抚顺矿务局总医院医学影像科,辽宁抚顺113000

出　　处：《现代肿瘤医学》2018年第13期2090-2093,共4页Journal of Modern Oncology

摘　　要：目的:研究表柔比星分别联合碘油与Hepasphere载药微球对经皮肝动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)治疗肝癌患者的疗效及预后分析。方法:选取病例被随机分为两组,分别注射表柔比星与碘油(A组)、表柔比星与Hepasphere微球混合液(B组)。1个月后对比术前及术后肝肾功、AFP,并采用mRECIST标准[疾病缓解率(CR+PR)、疾病控制率(CR+PR+SD)]对比两组之间差别。结果:A、B组患者术前、术后肝肾功等化验指标数值,组间和组内对比无统计学差异(P>0.05);A、B组患者TACE治疗前AFP差异无统计学意义(P>0.05),术后AFP差异有统计学意义(P<0.05);两组患者疾病缓解率、疾病控制率差异有统计学意义(P<0.05)。结论:表柔比星联合Hepasphere载药微球可以提高肝癌患者TACE的疗效。Objective：To study the efficacy and prognosis of epirubicin combined with lipiodol or Hepasphere loaded microspheres in the treatment of hepatocellular carcinoma （ HCC ） in transcatheter arterial chemoenlbolization （TACE）. Methods ：The patients were randomly divided into two groups ：Epirubicin and lipiodol （group A） ,epirubi cin and Hepasphere microspheres （group B） , respectively. After 1 month, the preoperative and postoperative liver and renal function, AFP, and mRECIST criteria including disease remission rate （ CR ＋ PR） and disease control rate （ CR ＋ PR ＋ SD） ,and the difference belween the two groups were compared. Results：In the A and B group patients before and after operation, comparison of liver and kidney function tests index values between and within groups showed no significant difference （ P 〉 0.05 ）. AFP before TACE in the two groups showed no significant difference （ P 〉 0.05 ）, and the difference was statistically significant after TACE （ P 〈 0.05 ）. Remission rate, control rate of two groups of patients were statistically significant （ P 〈 0.05 ）. Conclusion ： Epirubicin combined with Hepasphere loaded micro spheres can improve the efficacy of TACE in patients with hepatocellular carcinoma.

关 键 词：肝癌 载药微球 碘油 栓塞治疗 

分 类 号：R735.7[医药卫生—肿瘤]