热性惊厥患儿血清白细胞介素-1β白细胞介素-6和TNF-α水平变化及相关性研究  

Changes of IL-1β,IL-6 and TNF-α and correlation of the changes with febrile seizures in children

作　　者：陈豪 潘阳琼 张香敏[1] 张晓莉[1] 杜开先[1] 贾天明[1] 李小丽[1] CHEN Hao;PAN Yang-Qiong;ZHANG Xiang-Min(Department of Pediatrics,the Third Affiliated Hospital of Zheng-zhou University,Henan 450052,China)

机构地区：[1]郑州大学第三附属医院儿内科,河南450052 [2]郑州儿童医院急诊科,河南450052

出　　处：《中国临床新医学》2018年第6期528-531,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：河南省医学科技攻关计划项目(编号:201702102)

摘　　要：目的探讨热性惊厥(febrile seizures,FS)患儿血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平变化,分析三者在FS患儿血清中水平的相关性,进一步研究它们与儿童FS发病的关系。方法选取2016-07~2017-07该院收治的72例FS患儿,将其分为单纯性热性惊厥(SFS)组40例和复杂性热性惊厥(CFS)组32例。选取同期在该院体检且年龄和性别相匹配的50名儿童作为健康对照组。采用双抗体夹ELISA法对血清中IL-1β、IL-6、TNF-α的水平进行测定。结果 FS组患儿血清IL-1β、IL-6及TNF-α水平均高于健康对照组,差异均有统计学意义(P<0.05);SFS组患儿血清IL-1β、IL-6及TNF-α水平均低于CFS组,差异均有统计学意义(P<0.05);IL-1β、IL-6及TNF-α在FS患儿血清中的水平均呈正相关(P均<0.05)。结论儿童血清IL-1β、IL-6及TNF-α水平升高与FS发生密切相关,三者有协同作用。Objective To investigate the changes of interleukin-1β（ IL-1β）,interleukin-6（ IL-6） and tumour necrosis factor-alpha（ TNF-α） and the correlation of the changes with febrile seizures（ FS） in children. Methods 72 children with FS were divided into the simple FS（ SFS） group（ n = 40） and the complex FS（ CFS） group（ n =32）. 50 healthy children with matched age and sex were taken as the control group. Enzyme Linked Immunosorbent Assay（ ELISA） was used to detect the serum levls of IL-1β,IL-6 and TNF-α. Results The levels of serum IL-1β,IL-6 and TNF-α in the FS group were all significantly higher than those in the healthy control group（ P〈0. 05）. The levels of serum IL-1β,IL-6 and TNF-α in the SFS group were all significantly lower than those in the CFS group（ P〈0. 05）. There was a positive correlation between the levels of IL-1β,IL-6 and TNF-α and FS in children（ P〈0. 05）. Conclusion The increased levels of IL-1β,IL-6 and TNF-α are correlated with the attack of FS,and have a synergistic effect on FS.

关 键 词：儿童 热性惊厥 白细胞介素-1Β 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R72[医药卫生—儿科]