半胱氨酸蛋白酶L在卵巢癌中的研究进展  

Research Progress of Cathepsin L in Ovarian Cancer

作　　者：刘丽 汪希鹏 LIU Li;WANG Xi-peng(Department of Gynecology,Affiliated First Maternity and Infant Hospital of Tongji University,Shanghai 201204,China;Department of Gynecology and Obstetrics,Xinhua Hospital,Shanghai Jiao Tong University Shanghai 200092,China)

机构地区：[1]同济大学附属第一妇婴保健院妇科,上海201204 [2]上海交通大学附属新华医院妇产科

出　　处：《国际妇产科学杂志》2018年第3期310-313,共4页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(81072136;81372787);上海市市级医疗卫生学科建设项目(2017ZZ020)

摘　　要：卵巢癌的早期发现率低,70%以上的患者诊断时已为进展期,由于广泛转移和耐药,其预后极差。半胱氨酸蛋白酶L(CTSL)是半胱氨酸蛋白酶家族的主要成员之一,可分布于细胞内或分泌到细胞外基质,以细胞内外多种蛋白为底物。CTSL在多种恶性肿瘤组织中表达水平增高,卵巢癌组织和卵巢癌患者血清中CTSL的水平也异常增高。CTSL促进卵巢癌的生长、转移、耐药、血管生成等恶性生物学行为。血清CTSL与其他生物标记联合应用有利于早期诊断卵巢癌,同时实验研究表明以CTSL为靶点的治疗对控制卵巢癌的进展有较好的效果。因此对CTSL在卵巢癌进展中的作用机制进行更深入的探讨有望为卵巢癌的早期诊断和治疗提供新的思路。The early detection rate of ovarian cancer is low, and more than 70 percentages of patients are diagnosed at advanced stages. The prognosis is too poor because of widespread metastasis and chemoresistance. Cathepsin L（CTSL） is an important member of cathepsin family, distributing intracellularly and extracellularly and participating in the degradation of diverse proteins. CTSL is overexpressed in a variety of malignant tumor tissues and the level of CTSL is high in ovarian cancer tissues and the serum of patients. CTSL can promote the growth, metastasis, chemoresistance and angiogenesis of ovarian cancer.Serum CTSL level is helpful in the diagnosis of ovarian cancer in combination with other biological markers. On the other hand,experimental researches have revealed that targeting CTSL is effective to control the progression of ovarian cancer. Therefore,investigating the role of CTSL in the progression of ovarian cancer more deeply is promising to supply more clues for the diagnosis and therapy of ovarian cancer, and here we will review the progression in this area.

关 键 词：卵巢肿瘤 半胱氨酸内肽酶类 肿瘤转移 抗药性 肿瘤 半胱氨酸蛋白酶L 

分 类 号：R737.31[医药卫生—肿瘤]