7.0T静息态fMRI分析恒河猴脑默认网络  

Investigation of default mode networks in rhesus macaque brain with 7.0 Tresting-state fMRI

作　　者：付晓薇[1,2] 郭承珍 杨丹洲 张迎 FU Xiaowei;GUO Chengzhen;YANG Danzhou;ZHANG Ying(College of Computer Science and Technology,Wuhan University of Science and Technology,Wuhan 430065,China;Hubei Province Key Laboratory of Intelligent Information Processing andReal-time Industrial System,Wuhan 430065,China;College of Pharmacy,Purdue University,West Lafayette 47907,USA;Institute of Biophysics,Chinese Academy ofScience,Beijing 100101,China;State Key Laboratory of Brain andCognitive Science,Beijing 100101,China)

机构地区：[1]武汉科技大学计算机科学与技术学院,湖北武汉430065 [2]智能信息处理与实时工业系统湖北省重点实验室,湖北武汉430065 [3]普渡大学药学院,西拉法叶47907 [4]中国科学院生物物理研究所,北京100101 [5]脑与认知科学国家重点实验室,北京100101

出　　处：《中国医学影像技术》2018年第6期801-806,共6页Chinese Journal of Medical Imaging Technology

基　　金：国家重点基础研究发展计划(973计划)项目(2012CB825500);中国留学基金委资助项目(201408420205);湖北省自然科学基金(2017CFB506);湖北省高校省级教学改革研究项目(2016234);智能信息处理与实时工业系统湖北省重点实验室开放课题项目(2016znss02A);武汉科技大学研究生院教研项目(Yjg201614;Yjg201613);大学生创新基金研究项目(16ZRA072)

摘　　要：目的分析健康恒河猴大脑的默认网络(DMN)结构。方法采用7.0TfMRI获得麻醉状态下健康恒河猴的静息态数据;以DPARSF软件包对猴脑静息态功能像进行预处理,将其配准到恒河猴标准模板112SM-RL-T1;之后利用GIFT软件包对预处理后的功能像数据进行组独立成分分析。结果本文方法可较准确地对猴脑静息态数据进行预处理,并获得静息态脑网络功能连接图;其中DMN包括位于中线区的后扣带回、前扣带回、内侧顶叶皮质、后压部皮质以及大脑左右半球较为对称的腹侧壁内区域、背侧颞上沟回、颞区、弓状沟回及部分视觉区域等脑区。结论借助7.0TfMRI,本文证实恒河猴默认网络与人类默认网络在结构上具有相似性,此类模型可辅助进行药理性实验研究以及神经认知类研究。Objective To investigate default mode networks（DMN）in healthy rhesus monkey brain.Methods Under anesthesia,two healthy rhesus macaques underwent resting-state fMRI at a 7.0T MR scanner.The functional images were firstly normalized to the standard rhesus monkey template 112 SM-RL-T1,and the GIFT software was aplied to conduct group-level independent component analysis on all preprocessed functional images.Results The functional connectivity maps of the resting-state networks of rhesus macaques were obtained using this method.DMN bilaterally included posterior cingulate cortex,anterior cingulate cortex,medial parietal cortex,retrosplenial cortex,arcuate sulcus,ventral intraparietal area,temporoparietal area,superior temporal sulcus dorsal bank and a portion of visual cortex.Conclusion With the help of cutting-edge 7.0T fMRI technology,It was demonstrated that DMN of rhesus macaque brain highly resembled the ones in human,which could support the notion that non-primates are useful models for neuropharmacological and neurocognitive studies.

关 键 词：磁共振成像 恒河猴 默认网络 独立成分分析 

分 类 号：R-332[医药卫生] R445.2