复发缓解型多发性硬化患者急性发作期血清尿酸与肌酐的水平变化及意义  

Changes and significance of serum uric acid and creatinine in patients with relapsing remitting multiple sclerosis at acute stage

作　　者：刘芳[1] 赵兴军[1] 孟颖[1] 刘志辉[1] 刘君玲[1] LIU Fang;ZHAO Xingjun;MENG Ying;LIU Zhihui;LIU Junling(Weifang Medical University,Weifang 261053,China)

机构地区：[1]潍坊医学院,山东潍坊261053

出　　处：《中国实用神经疾病杂志》2018年第12期1309-1313,共5页Chinese Journal of Practical Nervous Diseases

基　　金：山东省自然科学基金(联合专项)(编号:ZR2015HL042);潍坊市科学技术发展计划项目(编号:2015WS050);潍坊市卫生计生委科研项目计划(编号:2016WSJS089)

摘　　要：目的探讨复发缓解型多发性硬化(multiple sclerosis,MS)患者急性发作期血清尿酸(uric acid,UA)和肌酐(serum creatinine,SCr)水平的变化及意义。方法收集117例复发缓解型MS急性发作期患者,同时收集性别、年龄匹配的125例门诊健康查体者为对照组。于次日06:00抽取空腹肘静脉血,测定血清UA、SCr浓度。结果 MS组血清UA水平明显低于对照组(P<0.001);女性患者UA值比较,差异有统计学意义(P=0.000);男性患者UA值比较,差异有统计学意义(P=0.017)。MS组血清SCr水平较对照组明显降低(P<0.001);女性患者血清SCr水平比较,差异有统计学意义(P=0.002);男性患者血清SCr水平比较,差异有统计学意义(P=0.000)。MS中女性患者高尿酸血症的患病率低于男性。Pearson相关分析显示,复发缓解型MS患者急性发作期血清UA和SCr水平无相关性。结论血清UA、SCr水平的降低可能与MS患者急性发作期有关,UA、SCr水平是MS的重要生化指标,值得注意的是MS患者中女性较男性不易发生高尿酸血症。Objective To investigate the changes and significance of serum uric acid acidine UAA and creatinine serum creatinine in patients with recurrent and remission multiple sclerosis（MS）.Methods 117 patients with relapsed and remission MS were collected,of whom 82 were female and 35 were male.At the same time,125 outpatient health examiners were collected as control group.Fasting cubitus venous blood was collected at 06：00 am and serum UA,SCR concentration was measured.ResultsThe UA level of blood group MS was significantly lower than the control group,P=0.000.Compare the uric acid values of males and females respectively（female,P=0.000;men,P=0.017）.MS blood group the level of SCr was significantly lower than the control group,P=0.000.Compare the creatinine values of males and females respectively（female,P=0.002;male,P=0.000）.The prevalence of hyperuricemia in women was lower than that in men.Pearson correlation analysis showed no correlation between serum UA and SCr levels in patients with relapsed and remission MS.Conclusion The decrease of serum UA,SCR level may be related to the acute attack stage of MS patients.UA and SCR levels are important biochemical indicators of MS.It is worth noting that women are less likely to develop hyperuricemia than men in MS patients.

关 键 词：多发性硬化 尿酸 肌酐 高尿酸血症 脱髓鞘疾病 复发缓解型 

分 类 号：R744.51[医药卫生—神经病学与精神病学]