早期梗塞后抑郁患者观看情绪图片后VBA-DTI研究  

VBA-DTI Study in Patients with Early PSD after Watching Emotional Images

作　　者：陈宇[1] 吴明祥[1] 陈文娇 龚静山[1] 徐坚民[1] 邹良玉 张景忠[1] 李刚 CHEN Yu;WU Ming-xiang;CHEN Wen-jiao(Department of Radiology,The Second Medical College of Jinan University/Shenzhen People＇s Hospital,Shenzhen 518020,Guangdong Province,China)

机构地区：[1]暨南大学第二临床医学院(深圳市人民医院)放射科 [2]暨南大学第二临床医学院(深圳市人民医院)神经内科,广东深圳518020

出　　处：《中国CT和MRI杂志》2018年第7期50-54,共5页Chinese Journal of CT and MRI

基　　金：深圳市科创委课题(编号JC YJ20150403102020233)和(编号JCYJ20160422170522 075);深圳市卫计委课题(编号201601015)

摘　　要：目的运用基于体素分析法(VBA)探讨早期梗塞后抑郁症(PSD)观看情绪图片后的脑白质微观结构。方法对21例梗塞后抑郁症患者(PSD)和22例梗塞后无抑郁症组(PSND)、20例正常对照组(NC)受试者观看情绪图片后行全脑弥散张量成像扫描。应用VBA方法对PSD组和2个对照组的FA值进行组间比较。结果 PSD组-NC组差异显著的脑区主要有双侧额叶、顶叶(皮层为主),胼胝体前部、体部及压部,扣带回体部,放射冠,基底节区(丘脑、豆状核、左侧内囊),双侧小脑半球(P<0.05);PSD组-PSND组差异显著的脑区主要有双侧额顶叶内侧皮层(P<0.05);PSND组-NC组差异显著的脑区主要有双侧扣带回,左侧胼胝体前部及压部(P<0.05)。结论早期PSD患者存在脑白质损伤,观看情绪图片后主要表现为边缘系统-皮质-纹状体-苍白球-背侧丘脑(LCSPT)神经环路的损伤,提示早期PSD可能与神经网络损伤程度有关。Objective To investigate the microstructural abnormalities of white matter in patients with post-stroke depression（PSD） by using the method of voxel-based analysis（VBA）. Methods Whole brain diffusion tensor imaging（DTI） was performed in 21 patients with PSD and 22 stroke patients without depression group（PSND）, 20 healthy volunteers as control group（NC）. Fractional anisotropy（FA） values were compared between PSD group and 2 control groups by VBA. Results The FA values differences with statistical significance of brain regions were found in following（P〈0.05）： between the PSD group and the NC group, mainly include bilateral frontal lobe and parietal lobe（cortex mainly）, the anterior, body and splenium parts of the corpus callosum, the body of cingulate gyrus, corona radiata, basal ganglia（Thalamus, putamen, left internal capsule） and bilateral cerebellar hemisphere（P〈0.05）, between the PSD group-PSND group, mainly include bilateral medial frontal lobe and parietal lobe cortex（P〈0.05）, between the PSND group-NC group, mainly include bilateral cingulate gyrus, left anterior and splenium parts of corpus callosum（P〈0.05）. Conclusion The microstructural abnormalities of white matter were found in patients with early PSD, and mainly expressed as the injury of the nerve loop of the limbic system-cortex-striatum-globus pallidus-dorsal thalamus（LCSPT）, which suggested that early PSD may be related to the degree of neural network damage.

关 键 词：梗塞后抑郁症 情绪图片 弥散张量成像 

分 类 号：R364.17[医药卫生—病理学]