局部复发鼻咽癌患者的临床特征及癌组织Ki-67与Epstein-Barr病毒编码小RNA的表达水平  

Expression levels of carcinoma tissues Ki-67 and Epstein-Barr virus-encoded small RNA and clinical features of locally recurrent nasopharyngeal carcinoma

作　　者：李冰[1] 翁敬锦[1] 韦嘉章[1] 兰桂萍[1] 司勇锋[1] LI Bing;WENG Jing-jin;WEI Jia-zhang;LAN Gui-ping;SI Yong-feng(Department of Otolaryngology Head and Neck,the People＇s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院耳鼻咽喉头颈科,南宁市530021

出　　处：《广西医学》2018年第11期1164-1167,共4页Guangxi Medical Journal

基　　金：广西科学研究与技术开发计划(桂科攻1355005-3-9;14124003-3);广西医药卫生科研课题(Z2013402)

摘　　要：目的探讨局部复发鼻咽癌患者的临床特征及癌组织Ki-67与Epstein-Barr病毒编码小RNA(EBER)的表达水平。方法纳入53例局部复发的鼻咽癌患者,比较其初治及复发时的临床特征,分别用免疫组织化学和原位杂交技术检测初治及复发时组织标本中Ki-67和EBER的表达情况,并观察组织病理特征。结果局部复发和初治时鼻咽癌的原发肿瘤-区域淋巴结-远处转移(TNM)分期及T分期比较差异无统计学意义(P>0.05),患者复发时N1+N2+N3期比例低于初治时比例(P<0.05);初治及局部复发性鼻咽癌组织Ki-67的表达比较差异无统计学意义(P>0.05);Ki-67阳性的局部复发性鼻咽癌患者,不同复发时间其Ki-67表达差异无统计学意义(P>0.05)。局部复发性鼻咽癌组织中EBER表达强度弱于初治鼻咽癌(P<0.01)。结论与初发时相比,局部复发鼻咽癌患者远处转移倾向小,肿瘤细胞增殖能力相似,但EBER表达下降,应考虑手术治疗。Objective To investigate the expression levels of carcinoma tissues Ki-67 and Epstein-Barr（EB） virus-encoded small RNA（EBER） in patients with locally recurrent nasopharyngeal carcinoma. Methods Fifty-three patients with locally recurrent nasopharyngeal carcinoma were enrolled in the study,and their clinical features in the initial treatment and recurrence were compared.Immunohistochemistry and in situ hybridization were adopted to detect the expressions of Ki-67 and EBER in specimens from the 53 patients in the initial treatment and recurrence,and the histopathological features were observed. Results There was no significant difference in the tumor-node-metastasis（TNM） stage or stage T between the patients with locally recurrent and newly diagnosed nasopharyngeal carcinoma（ P 〉0.05）,the proportion of stage N1,N2 and N3 of recurrent patients was lower than that in their initial treatment（ P 〈0.05）;no significant difference was found in the expression of carcinoma tissues Ki-67 between the patients with newly diagnosed and locally recurrent nasopharyngeal carcinoma （ P 〉0.05） ;among the Ki-67 positive patients with locally recurrent nasopharyngeal carcinoma,there was no significant difference in the expression of Ki-67 among different recurrence time points（ P 〉0.05）.The expression of EBER in carcinoma tissues from locally recurrent nasopharyngeal carcinoma was weaker than that in newly diagnosed nasopharyngeal carcinoma（ P 〈0.01）. Conclusion The locally recurrent nasopharyngeal carcinoma has less risks of distant metastasis and similar proliferation capability compared to the newly diagnosed nasopharyngeal carcinoma,presenting decreased expression of EBER,and surgical therapy should be considered.

关 键 词：鼻咽肿瘤 局部复发 临床特征 Epstein-Barr病毒编码的小RNA KI-67 

分 类 号：R739.62[医药卫生—肿瘤]