不同剂量奥美拉唑对老年胃溃疡穿孔腹腔镜修补术疗效和并发症的影响  

Effects of Different Doses of Omeprazole on the Efficacy and Complications of Laparoscopic Repair for Elderly Gastric Ulcer Perforation

作　　者：何启雄 张绪鹏[1] 李盛海 黄铭祥 周成茂 谢启明[1] HE Qixiong, ZHANG Xupeng , LI Shenghai, HUANG Mingxiang, ZHOU Chengmao, XIE Qiming(Department of Surgery, the Affiliated Hospital of Zhooqing Medical College, Zhaoqing 526060, China)

机构地区：[1]肇庆医学高等专科学校附属医院外科,广东肇庆526060

出　　处：《临床医学工程》2018年第6期759-760,共2页Clinical Medicine & Engineering

摘　　要：目的探讨老年胃溃疡穿孔腹腔镜修补术患者给予不同剂量奥美拉唑对手术疗效及并发症的影响。方法选取76例行腹腔镜修补术的老年胃溃疡穿孔患者,随机分为干预组和常规组各38例,围手术期分别给予80 mg/d和40 mg/d剂量奥美拉唑,比较两组的手术疗效及并发症。结果两组的手术时间、术中出血量比较,差异无统计学意义(P>0.05);干预组患者的进食时间、拔管时间、住院时间均显著短于常规组(P<0.05)。干预组患者的再穿孔、腹腔感染及肠梗阻发生率均显著低于常规组(P<0.05)。结论给予老年胃溃疡穿孔腹腔镜修补术患者大剂量奥美拉唑治疗,可协助提高手术疗效,降低术后并发症发生率。Objective To explore the effects of different doses of omeprazole on the surgical efficacy and complications of laparo-scopic repair for elderly patients with gastric ulcer perforation. Methods 76 cases of elderly patients with gastric ulcer perforation who re-ceived laparoscopic repair were selected and randomly divided into two groups, with 38 cases in each group. During perioperative period, the intervention group received 80 mg/d omeprazole, and the regular group received 40 mg/d omeprazole. The surgical efficacy and complica-tions were compared between two groups. Results No statistical difference was found between two groups in the surgical time or intraoperative blood loss volume （P 〉0.05）, while the eating time, extubation time and hospitalization time of intervention group were significantly shorter than those of regular group （P 〈0.05）. The incidences of reperforation, abdominal infection and intestinal obstruction of intervention group were significantly lower than those of regular group （P 〈0.05）. Conclusions High-dose omeprazole treatment for elderly gastric ulcer perfo-ration patients with laparoscopic repair can auxiliary improve the surgical efficacy, and reduce the incidence ofpostoperative complications.

关 键 词：老年 胃溃疡穿孔 腹腔镜修补术 奥美拉唑 

分 类 号：R573.1[医药卫生—消化系统]