灵芝多糖颗粒剂的处方优化研究  

Study on Formulation Optimization of Ganoderma Lucidum Polysaccharide Granules

作　　者：吕兴萍[1] 郑小莹 刘海燕 杨薇红[1] L Xing-ping,ZHENG Xiao-ying,LIU Hai-yan et al(Jiangsu Vocational College of Agriculture and Forestry, Jurong,Jiangsu 21240)

机构地区：[1]江苏农林职业技术学院,江苏句容212400

出　　处：《安徽农业科学》2018年第18期150-152,162,共4页Journal of Anhui Agricultural Sciences

基　　金：江苏农林职业技术学院科技项目(28014019)

摘　　要：[目的]研究制备灵芝多糖颗粒剂的最优处方。[方法]以颗粒的粒度、吸湿性、制粒难易度、口感等为指标,通过单因素试验考察稀释剂、润湿剂等的影响,再用正交试验优选最优处方。[结果]最优处方是稀释剂为糊精∶乳糖(1∶1),润湿剂为70%乙醇,每剂量中甜味剂阿斯巴甜添加量为0.025 g。[结论]在最优处方条件下所制备的颗粒是口感好、溶解快、吸湿性小的合格颗粒剂。[Objective] The research aimed to study the optimal formulation of Ganoderma lucidum polysaccharide granules.[Method]Taking the particle size, hygroscopicity, difficulty in granulation and taste as indicators, the effects of diluents and wetting agents were examined by single-factor tests, and then the optimal prescription was optimized by orthogonal test.[Result]The optimal formulation was dextrin ∶lactose （1 ∶1） for the diluent, 70% ethanol for the wetting agent, and 0.025 g of aspartame for each sweetening agent.[Conclusion]The granules prepared under the optimal formulation conditions are good granules with good taste, fast dissolution and low hygroscopicity.

关 键 词：灵芝多糖 颗粒剂 处方优化 单因素试验 正交试验 

分 类 号：R286[医药卫生—中药学]