c-Met与HER-2、HIF-1α在胃癌中的表达及临床意义  

Expression of c-Met,HER-2 and HIF-1α in Gastric Carcinoma and Clinical Significance

作　　者：叶明[1] 张冉[1] 李泽霖 林晨 岳娜[1] Ye Ming;Zhang Ran;Li Zelin(Department of Pathology,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院病理科,乌鲁木齐830011 [2]新疆医科大学第六附属医院病理科,乌鲁木齐830000

出　　处：《华中科技大学学报（医学版）》2018年第3期339-343,共5页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：新疆医科大学科研创新基金资助项目(No.XYDCX201557)

摘　　要：目的研究c-Met、人类表皮生长因子(HER-2)及低氧诱导因子(HIF-1α)在胃癌组织中的表达及与临床病理学特征的关系。方法采用免疫组织化学法检测78例胃癌组织和41例癌旁正常胃组织中c-Met、HER-2及HIF-1α的表达,并分析胃癌中c-Met、HER-2及HIF-1α的表达与临床病理特征的关系。结果 c-Met、HER-2以及HIF-1α在胃癌组织中的阳性表达率显著高于癌旁正常组织,差异具有统计学意义(均P<0.05)。其中,HIF-1α蛋白的表达分别与胃癌组织的分化程度及临床分期、淋巴结转移相关(均P<0.05);c-Met的表达与胃癌分化程度及淋巴结转移相关(均P<0.05);HER-2的表达则与胃癌分化程度及临床分期相关(均P<0.05)。HIF-1α的表达与HER-2、c-Met的表达呈正相关(均P<0.05);HER-2与c-Met的表达无相关性(P>0.05)。结论 c-Met与HER-2、HIF-1α均与胃癌的侵袭转移密切相关,有望成为胃癌靶向治疗及临床监测的重要生物学指标。Objective To study the relationship of the expression of c-Met,human epidermal growth factor（HER-2）and hypoxia-inducible factor（HIF-1α）with the clinicopathological features of gastric carcinoma.Methods The expression of c-Met,HER-2 and HIF-1αin 78 cases of gastric carcinoma and 41 cases of normal gastric tissues was detected by immunohistochemical method.The relationship between the expression of c-Met,HER-2 and HIF-1αand clinicopathological factors in gastric carcinoma was analyzed.Results The positive rate of c-Met,HER-2 and HIF-1αwas significantly higher in gastric cancer than in adjacent tissues（P〈0.05）.The expression of HIF-1αwas significantly correlated with the degree of differentiation,clinical stage and lymph node metastasis in gastric carcinoma（P〈0.05）.The expression of c-Met was significantly correlated with the degree of differentiation and lymph node metastasis（P〈0.05）,while HER-2 was significantly correlated with the degree of differentiation and clinical stage in gastric carcinoma（P〈0.05）.The expression of HER-2 and c-Met was positively correlated with the expression of HIF-1α（P〈0.05）.There was no correlation between the expression of HER-2 and c-Met（P〉0.05）.Conclusion c-Met and HER-2 and HIF-1αcan be used as biological indicators of invasion and metastasis of gastric cancer,providing a theoretical basis for the targeted treatment of gastric cancer,and can be used as a basis for clinical monitoring indicators.

关 键 词：胃癌 C-MET 人类表皮生长因子-2 低氧诱导因子-1Α 

分 类 号：R735.2[医药卫生—肿瘤]