帕金森病的早期症状与诊断方法研究进展  

Research Advances in Early Symptoms and Diagnostic Methods of Parkinson's Disease

作　　者：王营飞 贺娟[1] 张学敏 WANG Yingfei;HE Juan;ZHANG Xuemin(Department of Neurology,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China)

机构地区：[1]内蒙古医科大学附属医院神经内科,呼和浩特010030

出　　处：《医学综述》2018年第12期2441-2445,共5页Medical Recapitulate

摘　　要：帕金森病(PD)又称震颤麻痹,是第二大常见的神经系统退行性疾病,为黑质神经元丢失出现的纹状体多巴胺缺乏所致,黑质神经元胞内包涵体含有α-突触核苷聚集物,是PD的神经病理标志。PD包括一系列运动性与非运动性症状,但早期症状不典型,患者多不能自行发现,且会影响工作、生活等,故早期诊断显得尤为重要。以往多通过患者的运动性症状来进行诊断,但发现后多为中晚期,患者预后不良。未来,随着对PD认识的逐渐深入,其诊断将更加完善。Parkinson＇s disease（ PD）,also known as tremor palsy,is the second most common degenerative disease of the nervous system,due to the striatal dopamine deficiency that appears in the loss of substantia nigra neurons. The inclusion bodies of the substantia nigra neurons contain α-synaptic nucleoside aggregation,which is a neuropathological sign of PD.PD includes a series of motor and non-motor symptoms,but the early symptoms are not typical,which mostly cannot be noticed by the patients themselves,and will affect the work and life of the patients,so early diagnosis is particularly important. In the past,most of the patients were diagnosed by motor symptoms,but most cases were already in the middle and late stage,and the prognosis was poor. In the future,with the gradual deepening of PD understanding,its diagnosis will be further improved.

关 键 词：帕金森病 早期症状 早期诊断 

分 类 号：R742.5[医药卫生—神经病学与精神病学]