丹参在逆转肿瘤耐药及化疗增敏中的研究进展  

Advancement of Salvia miltiorrhiza on reversing tumor resistance and chemotherapy sensitization

作　　者：金忠明 洪伟鹏 黄民[1] 金晶[1] JIN Zhong-ming;HONG Wei-peng;HUANG Min;JIN Jing(School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China)

机构地区：[1]中山大学药学院,广东广州510006

出　　处：《中国药理学通报》2018年第7期889-891,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81573658)

摘　　要：肿瘤耐药是导致临床化疗失败的主要原因之一,然而目前临床上尚无有效逆转肿瘤耐药的药物和策略。近年来,中药丹参在肿瘤治疗中的作用引起了越来越多学者的关注。丹参的药理活性成分主要包括脂溶性成分(丹参酮Ⅰ、丹参酮ⅡA、二氢丹参酮Ⅰ、隐丹参酮等)和水溶性成分(丹酚酸A、丹酚酸B、原儿茶醛等)两类。最近的研究发现,两者不仅具有不同程度的抗肿瘤活性,还对耐药肿瘤细胞表现出明显的耐药逆转作用,且与化疗药联用具有明显减毒增效作用。该文对近年来丹参在逆转耐药及化疗增敏中的研究进展做一综述,为丹参作为肿瘤耐药逆转和化疗增敏剂的研究开发和临床合理应用提供参考。At present,chemoresistance is one of the leading causes of chemotherapy failure but there is no effective drugs or strategies to reverse the resistance of chemotherapy.In recent years,the anticancer effect of Salvia miltiorrhiza receives wide attention of researchers.The major bioactive constituents in Salvia miltiorrhiza can be divided into two groups： liposoluble components（ tanshinone Ⅰ,tanshinone ⅡA,dihydrometanone Ⅰ and cryptotanshinone,etc.） and hydrophilic components（ salvianolic acid A,salvianolic acid B and protocatechualdehyde,etc.）.Recent studies have found that these components not only play different anti-tumor activities,but showed significant reversal resistance effects on drug-resistant tumor cells.Besides,with the combination of chemotherapy drugs,they have significant attenuated toxicity and synergistic effect.In this paper,we summarize the researches pertaining to the effects of Salvia Miltiorrhiza on the reversal of drug resistance and chemotherapy sensitization in recent years,providing references for the development of Salvia miltiorrhiza as multidrug resistance reversal agents and its rational application in clinic.

关 键 词：丹参 肿瘤 化疗 作用机制 逆转耐药 增敏 

分 类 号：R-05[医药卫生] R282.7