miR-142-3p在陕北地区结直肠癌患者中的表达及临床意义  

The expression of miR-142-3p in colorectal cancer of northern Shaanxi and its clinical significance

作　　者：宋依芯 吕向伟 尚会斌 成钧[4] 朱文侠[4] 王航辉 SONG Yi - xin1 , LV Xiang - wei2, SHANG Hui - bin3, CHENG Jun4, ZHU Wen - xia4, WANG Hang - hui1(1. Honghui Hospital, Xi＇an Jiaotong University, Xi＇an 710054, China, 2. Qishan Traditional Chinese Medicine Hospital, Shaanxi Province, Qishan 7224994, China, 3. Wugong County People＇s Hospital, Wugong 712200, China, 4. Medical College of Yan＇an University, Yan＇an 716000, China)

机构地区：[1]西安交通大学附属红会医院,陕西西安710054 [2]岐山县中医医院,陕西岐山722499 [3]武功县人民医院,陕西武功712200 [4]延安大学医学院局解教研室,陕西延安716000

出　　处：《延安大学学报（医学科学版）》2018年第2期9-11,共3页Journal of Yan'an University:Medical Science Edition

基　　金：陕西省教育厅科学研究计划项目(2013JK0754);中国博士后项目(2016M600804);陕西省博士后项目(2016BSHEDZZ92);西安市卫计委项目(J201602023);西安市红会医院项目(YJ2014008);西安市科技局项目(2017115FS/YX009(16))共同资助

摘　　要：目的观察微小microRNA 142-3p在陕北地区结直肠癌患者中的表达及临床意义。方法通过组织原位杂交,检测结直肠癌患者组织中miR-142-3p的表达。结果 miR-142-3p主要定位于细胞的胞浆,在癌组织和癌旁组织中miR-142-3p的表达存在差异。结论 miR-142-3p在陕北地区结直肠癌组织与癌旁组织中呈差异表达,有望成为结直肠癌诊断和治疗的潜在靶点。Objective To observe the expression of microRNA 142-3p in colorectal cancer of northern Shaanxi and its clinical significance.Methods The expression of miR-142-3p in the tissues of colorectal cancer was detected by in situ hybridization.Results miR-142-3p was mainly located in the cytoplasm of cells.The expression of mi-R142-3p was different in cancer tissues and adjacent tissues.Conclusion miR-142-3p was differentially expressed in colorectal cancer tissues and adjacent tissues of northern Shaanxi.It is expected to become a potential target for the diagnosis and treatment of colorectal cancer.

关 键 词：微小分子142-3p 结直肠癌 陕北地区 

分 类 号：R735.3[医药卫生—肿瘤]