增加盐酸帕洛诺司琼给药次数预防顺铂化疗致吐的疗效分析  

Effect of various frequency of palonosetron on preventing chemotherapy-induced nausea and vomiting

作　　者：王小勇[1] 陈诚[2] 许红霞[3] 杨杰[1] 李俊[4] 胡演坤 叶雨培 王晓华[3] WANG Xiaoyong;CHEN Cheng;XU Hongxia;YANG Jie;LI Jun;HU Yankun;YE Yupei;WANG Xiao-hua(Department of Oncology,Rugao People＇s Hospital,Nantong 226500,China;Department of Radio？therapy,Jiangsu Cancer Hospital ＆ Jiangsu Institute of Cancer Research,the Affiliated Cancer Hospital ofNanjing Medical University,Nanjing 210009,China;Department of Oncology,Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,the Affiliated Cancer Hospital of Nanjing Medical University,Nanjing210009,China;Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]如皋市人民医院肿瘤科,江苏南通226500 [2]南京医科大学附属肿瘤医院(江苏省肿瘤防治研究所,江苏省肿瘤医院)放疗科,江苏南京210009 [3]南京医科大学附属肿瘤医院(江苏省肿瘤防治研究所,江苏省肿瘤医院)肿瘤内科,江苏南京210009 [4]南京医科大学,江苏南京210029

出　　处：《中国肿瘤外科杂志》2018年第3期1-4,共4页Chinese Journal of Surgical Oncology

摘　　要：目的探讨增加盐酸帕洛诺司琼给药次数对预防含顺铂高度致吐性化疗所致恶心呕吐的有效性及安全性。方法回顾性分析如皋市人民医院2015年1月至2017年1月收治的接受含顺铂高度致吐性化疗100例恶性肿瘤患者临床资料,按盐酸帕洛诺司琼使用情况分为两组,研究组50例在化疗第1~3天治疗前30 min静脉推注盐酸帕洛诺司琼,对照组50例在化疗第1天和第3天治疗前30min静脉推注盐酸帕洛诺司琼,两组均观察1个化疗周期,统计研究组与对照组患者恶心、呕吐控制情况及给药安全性。结果研究组与对照组相比患者化疗急性期呕吐有效控制率差异无统计学意义(P>0.05),延迟期呕吐、延迟期恶心及延迟期食欲减退的有效控制率两组差异均有统计学意义(均P<0.05),其余不良反应两组差异无统计学意义(P>0.05)。结论接受含顺铂高度致吐性方案多日化疗患者中提高盐酸帕洛诺司琼给药次数,具有增强预防恶心呕吐疗效,不良反应轻等优点。Objective To evaluate the effects of various frequency of palonosetron on preventingnausea and vomiting induced by cisplatin chemotherapy. MethodsThe patients with malignant tumor acceptedcisplatin chemotherapy from January 2015 to January 2017 were divided into the treatment group （50 cases）and the control group （50 cases）. Patients in the control group were administered withpalonosetron 0. 25 mg,30 min before the cisplatin chemotherapy on day 1 and day 3. Patients in the treatment group were administeredwith palonosetron injection of 0. 25 mg, 30 min before the treatment on days 1 to3 of chemotherapy. All thepa-tients were observed for one cycle of chemotherapy. Occurrence situations of vomiting, nausea, and loss of ap-petite werecompared. ResultsIn the acute phase, vomiting control efficiency in the control group showed nostatistically difference compared to the treatmentgroup.In the delay phase, nausea andvomiting control efficien-cywas significantly different between the control groupand the treatment venting induced nausea and vomiting induced by cisplatinchemotherapy, and the adverse reactions could be tol？erant.

关 键 词：盐酸帕诺洛司琼 顺铂 恶心 呕吐 不良反应 给药次数 化疗 

分 类 号：R730.53[医药卫生—肿瘤]