BRAF^(V600E)和TERT启动子突变与甲状腺乳头状癌的关系  

The correlation between BRAF^(V600E) mutation and TERT promoter mutation with papillary thyroid carcinoma

作　　者：代丽丽 张国安 崔文[3] DAI Lili;ZHANG Guoan;CUI Wen(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250022,China;judicial Authentication Center,Jining Medical University;Jining Medical University,Jining 272067,China)

机构地区：[1]济南大学山东省医学科学院与生命科学学院,济南250022 [2]济宁医学院司法鉴定中心 [3]济宁医学院,济宁272067

出　　处：《济宁医学院学报》2018年第4期290-293,共4页Journal of Jining Medical University

基　　金：山东省高等学校科技计划(J13LK14)

摘　　要：近几年甲状腺癌的发病率呈逐渐上升趋势,是内分泌系统最常见的恶性肿瘤。甲状腺癌根据组织学特点分为4种病理类型,乳头状癌是其最常见的病理类型。在甲状腺乳头状癌的发生和发展中有多种基因参与,其中TERT启动子突变和BRAF^(V600E)基因突变在甲状腺乳头状癌的发生与发展中发挥着重要作用,并且可能与患者临床病理学特征和不良预后具有相关性。因此,正确全面了解TERT和BRAF^(V600E)基因在甲状腺乳头状癌中的突变特点以及相互作用有助于为甲状腺乳头状癌患者的预后判断和个体化诊治提供依据,从而为靶基因治疗奠定基础。Objective To understand the level of humanistic care ability of nursing undergraduates,analyze relevant influencing factors,and provide references for cultivating humanistic quality of nursing students.Methods By taking random cluster sampling method,160 people were selected to conduct the survey in 2015,2016 and 2017 of undergraduate nursing students in our school.General information questionnaire and Caring Ability Inventory （CAI） questionnaire were used.SPSS 17.0 was used to analyze the results with P〈0.05 for the statistically significant difference.Results The total score of humanistic care was the highest in 2017 （116.49±16.76）,and the difference was statistically significant （P〈0.05）.In the three grades,the courage dimension average score was the lowest（30.35±7.43）,and the cognitive dimension average score was the highest （46.81±7.00）.Students with harmonious atmosphere of daily life had strong humanistic care ability （P〈0.05）.The students who participated in the volunteer service behavior more than 5 times had a strong humanistic care ability （P〈0.05）.Conclusion School of humanities education course in the training plan as well as the related humanities program should have continuity and systemic,achieve all-round cultivation of nursing students humanities care quality,and improve the follow-up clinical human＇s practice ability.

关 键 词：甲状腺乳头状癌 BRAFV600E突变 TERT启动子突变 

分 类 号：R736.1[医药卫生—肿瘤]