基于“四时五藏阴阳”理论探讨日食对大鼠和小鼠下丘脑单胺类神经递质分泌的影响  

Effect of Solar Eclipse on the Secretion of Monoamine Neurotransmitters in Rat's Hypothalamus

作　　者：毕晋 刘晓燕[1] 王志飞[2] 郭霞珍[1] Bi Jin;Liu Xiaoyan;Wan Zhifei;Guo Xiazhen(Beijing Urtiversity of Chinese Medicine,Beijing 100029,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]北京中医药大学,北京100029 [2]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《世界中医药》2018年第5期1058-1062,1067,共6页World Chinese Medicine

基　　金：国家自然科学基金面上项目(30472113;81573840)

摘　　要：目的:利用日全食这一特殊的自然条件,根据"四时五藏阴阳"理论,研究日食对大鼠和小鼠下丘脑单胺类神经递质分泌的影响。方法:在日食前、日食中以及日食后取大鼠和小鼠下丘脑组织。利用高效液相法测定大鼠和小鼠下丘脑中单胺类递质的含量。结果:与日食前组、日食中组比较,日食后组大鼠和小鼠下丘脑中5-HIAA含量显著减少(P<0.01),5-HT含量显著减少(P<0.01)。结论:单胺类神经递质对日食产生的光照等变化反应灵敏,在日食条件下,下丘脑的单胺类神经递质含量有显著性变化,说明中医学"四时五藏阴阳"和"天人相应"理论具有科学的内涵。Objective ： To study the effects of changes in light conditions on the secretion of monoanfine neurotransmitters in the hy- pothalanms of rats by using the special natural conditions of total solar eclipse according to the ＂yin-yang of the four seasons and the five viscera＂ theory-. Methods：Rat hypothalanms was taken before, during, and after solar eclipse. The content of monoanline neurotransmitters in rat hypothalanms was determined by HPLC. Results ： Compared with the pre-eelipse group and the eclipse group, the content of 5-HIAA in the hypothalanms decreased significantly （ P〈0.01）,and 5-HT decreased significantly （ P 〈 0. 01 ）. Conclusion ： Monoamine neurotransmitters are sensitive to changes in the light environment. Under light sudden changes, the monoanline neurotransmitter content of the hypothalanms has a significant change.

关 键 词：四时五藏阴阳 日食 天人相应 下丘脑 单胺类神经递质 

分 类 号：R221[医药卫生—中医基础理论] R223.11[医药卫生—中医学]