对“四时五藏阴阳”理论生物学基础的探讨——时令季节对下丘脑-垂体-甲状腺轴功能节律的影响  

Discussion on Biological Basis of “Yin-yang of the Four Seasons and the Five Viscera”——Effects of Seasons on the Functional Rhythm of Hypothalamic-Pituitary-Thyroid Axis

作　　者：韩俊阁[1] 杨宗纯 张娜[2] 刘絮[2] 刘晓燕[2] 袁涛[1] 王效非[1] 王素梅[1] 郭霞珍[2] Han Junge;Yang Zongchun;Zhang Na;Liu Xu;Liu Xiaoyan;Yuan Tao;Wang Xiaofei;Wang Sumei;Guo Xiazhen(Beijing Fangshan Traditional Chinese Medicine Hospital,Beijing 102488,China;Beijing Urliversity of Chbwse Medicine,Beijing 100029,China)

机构地区：[1]北京市房山区中医医院,北京102488 [2]北京中医药大学,北京100029

出　　处：《世界中医药》2018年第5期1076-1081,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(81573840);北京中医药薪火传承"3+3"工程程士德名家研究室

摘　　要：目的:本研究观察了时令季节变化对下丘脑-垂体-甲状腺(HPT)轴功能的影响,以证实"四时五藏阴阳"理论的科学内涵。方法:检测了雄性金黄地鼠血浆中MT、TRH、TSH、T_3、T_4及甲状腺组织中MT、MR、T_3、T_4的含量。结果:发现血浆中MT、TRH、TSH、T_3、T_4含量呈现冬、春/秋高而夏至最低的变化趋势,甲状腺组织中MT、MR、T_3、T_4含量则呈现夏至最高而秋冬最低的变化趋势。结论:HPT轴的功能具有明显的季节相关性,在冬、春季节其机能相对增强,褪黑素可能为其季节性节律的调控因子,HPT轴的季节性功能变化为中医"四时五藏阴阳"理论提供了生物学依据。Objective：To systematically observe the effects of seasonal changes on the function of the hypothalamus-pituitary-thy-roid （HPT） axis to verify the scientific connotation of the ＂yin-yang of the four seasons and the five viscera＂ theory. Methods： The contents of MT, TRH, TSH, T3 , T4 in plasma and MT, MR, T3 , and T4 in the thyroid tissue of male golden hamster were measured. Results：The results showed that the contents of MT, TRH, TSH, T3 , and T4 in plasma showed the highest changes in winter, spring/autumn, and lowest in smnmer solstice. The contents of MT, MR, T3 , and T4 in thyroid tissue showed the highest changes in summer solstice and lowest in autumn and winter. Conclusion：The function of HPT axis has obvious seasonal correla tion, and its function is relatively enhanced in winter and spring. Melatonin may be a regulatory factor of this seasonal rhythm. The seasonal function change of HPT axis provides a biological basis for ＂yin-yang of the four seasons and the five viscera＂ theory.

关 键 词：四时五藏阴阳 褪黑素 下丘脑-垂体-甲状腺 时令季节 肾应冬 

分 类 号：R221[医药卫生—中医基础理论] R223.11[医药卫生—中医学]