TRIM28在肿瘤发生及胚胎发育中的作用  

Roles of TRIM28 in tumorigenesis and embryogenesis

作　　者：刘晔[1,2] 王尹瑜 许晶晶 黄荷凤[1,2] LIU Ye;WANG Yin-yu;XU Jing-jing;HUANG He-feng(Institute of Embryo-Fetal Original Adult Disease,The International Peace Maternity and Child Health Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;The Key Laboratory of Reproductive Genetics（Ministry of Education）,Zhejiang University School of Medicine,Hangzhou 310058,China)

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院胚胎源性疾病研究所,上海200030 [2]浙江大学医学院生殖遗传教育部重点实验室,杭州310058

出　　处：《上海交通大学学报（医学版）》2018年第7期835-840,共6页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海交通大学医学院博士创新基金(BXJ201640)~~

摘　　要：TRIM28是一个包含多个结构域的大分子蛋白,属于人类三聚体蛋白家族中的一员。该家族共计包含60余种蛋白,以存在4个保守结构域即RING指、B-box 1型和2型以及亮氨酸卷曲螺旋结构为主要特征。TRIM28主要与含KRAB结构域(Kruppelassociated box domain)的转录因子相互作用,从而发挥转录共激活或共抑制作用,并在肿瘤发生、细胞分化、胚胎发育的调控中发挥重要作用。TRIM28,known as a kind of macro-molecules,consists of multiple domains and belongs to one of human tripartite motif-containing proteins families.This superfamily contains more than 60 proteins in total and is characterized by four conservative domains,also referred to the RBCC domain,which is a RING（really interesting new gene） finger,two B-boxes（type 1 and type 2） and a leucine zipper coiled-coil region.TRIM28 plays its pivotal roles in transcriptional co-activation or co-repression by interacting directly with transcription factors,within which is a Kruppel-associated box domain（KRAB domain）.Moreover,it is critical during the development of embryos,the differentiation of cells and the regulation of cancers.

关 键 词：转录调节 共激活子 共抑制子 肿瘤 表观遗传 甲基化 

分 类 号：R73[医药卫生—肿瘤]