幼儿园单纯性肥胖儿童全血肉碱水平调查分析  

Analysis on the level of whole blood carnitine of kindergarten children with simple obesity

作　　者：赵庆伟[1] 闫承生[1] 马书军[1] 裴菊英[1] 王立宁[1] 刘云[1] 马东云[1] ZHAO Qing Wei;YAN Cheng Sheng;MA Shu Jun;Pei Ju Ying;WANG Li Ning;LIU Yun;MA Dong Yun(Hebei Provincial Women and Children＇s Health Center, Shijiazhuang 050031, China)

机构地区：[1]河北省妇幼保健中心,石家庄050031

出　　处：《中国妇幼卫生杂志》2018年第4期65-69,共5页Chinese Journal of Women and Children Health

基　　金：中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究基金资助(2016FYH018);2018年度河北省医学科学研究重点课题(20180946)

摘　　要：目的研究石家庄市区省直幼儿园儿童单纯性肥胖发生率及单纯性肥胖儿童全血31种肉碱水平,探讨全血肉碱水平与儿童肥胖的关系,为临床诊断和治疗干预提供科学依据。方法对省直幼儿园全体3~6岁3516例儿童进行体检,随机选出54例单纯性肥胖儿童做为观察组,按照1∶1配对原则选出54名正常体重儿童作为对照组,采用串联质谱法对以上儿童进行全血肉碱测定,利用SPSS11.0统计软件包进行数据处理。结果观察组患儿的全血肉碱水平存在不平衡,其中血游离肉碱(CO)、乙酰肉碱(C2)、丙酰肉碱(C3)、3-羟基异戊酰肉碱(C5-OH)、异戊酰肉碱(C5)、异戊烯酰肉碱(C5:1)、辛烯酰肉碱(C8:1)、葵二烯酰肉碱(C10:2)、3-羟基-十四碳酰肉碱(C14OH)、十六碳酰肉碱(C16)、十六碳烯酰肉碱(C16:1)、18碳烯酰肉碱(C18:1)、18碳二烯酰肉碱(C18:2)高于对照组,差异有统计学意义(P<0.05);丙二酰肉碱(C3DC)、丁酰肉碱(C4)、戊二酰肉碱(C5DC)、已酰肉碱(C6)、已二酰肉碱(C6DC)、辛酰肉碱(C8)、葵酰肉碱(C10)、葵烯酰肉碱(C10:2)、十二碳酰肉碱(C12)、十二碳烯酰肉碱(C12:1)、十四碳酰肉碱(C14)、十四碳烯酰肉碱(C14:1)、十四碳二烯酰肉碱(C14:2)、3-羟基-十六碳酰肉碱(C16OH)、3-羟基-十六碳烯酰肉碱(C16:1 OH)、18碳酰肉碱(C18)、3-羟基-十八碳酰肉碱(C18OH)、3-羟基-十八碳烯酰肉碱(C18:1 OH),两组间差异均无统计学意义(P均>0.05)。结论单纯性肥胖儿童多种全血肉碱水平高于正常体重儿童,动态监测肥胖儿童血肉碱水平,可以为临床医生对单纯性肥胖儿童进行干预提供科学依据。Objective To study the incidence of simple obesity of children in kindergarten and the level of 31 kinds of whole blood carnitine of children with simple obesity,to explore the relationship between the level of whole blood carnitine and childhood obesity,and to provide the scientific evidence for clinical diagnosis and treatment of children with simple obesity. Method A total of 3516 children aged 3-6 years old were performed physical examination. Among the 3516 children,54 children with simple obesity were selected as observation group and 54 children with normal weight were selected as control group. The levels of carnitine of the two groups were detected by Tandem mass spectrometry（MS/MS）. The data was processed by SPSS11. 0 statistical software package.Result There was imbalance of the level of whole blood carnitine in the twogroups. The level of CO、C2、C3 、C5-OH、C5、C5： 1、C8：1、C10： 2、C14 OH、C16、C16： 1、C18： 1、C18： 2 of observation group were higher than those of the control group. The difference was statistically significant（P 〈0. 05）. There was no difference in the levels of C3 DC、C4、C5 DC、C6、C6 DC、C8、C10、C10： 2、C12、C12：1、C14、C14： 1、C14： 2、C16 OH、C16： 1 OH、C18、C18 OH、C18： 1 OH between the two groups（P 〉0. 05）. Conclusion The whole blood carnitine levels of children with simple obesity is higher than the children with normal weight. Dynamic monitoring of blood carnitine levels can provide a scientific evidence for clinicians to make intervention to children with simple obesity.

关 键 词：儿童 单纯性肥胖 串联质谱 肉碱 

分 类 号：R175[医药卫生—妇幼卫生保健]