Current Status of Neuromodulatory Therapies for Disorders of Consciousness  

作　　者：Xiaoyu Xia Yi Yang Yongkun Guo Yang Bai Yuanyuan Dang Ruxiang Xu Jianghong He 

机构地区：[1]Department of Neurosurgery, PLA Army General Hospital [2]Department of Neurosurgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University [3]International Vegetative State and Consciousness Science Institute, Hangzhou Normal University

出　　处：《Neuroscience Bulletin》2018年第4期615-625,共11页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (81771128);the Beijing Municipal Science & Technology Commission (Z171100001017162 and Z161100000516165)

摘　　要：Treatment for disorders of consciousness （DOCs） is still a Gordian knot. Evidence-based guidelines on the treatment of DOC patients are not currently available, while neuromodulation techniques are seen as a potential treatment. Multiple neuromodulation therapies have been applied. This article reviews the most relevant studies in the literature in order to describe a clear picture of the current state of neuromodulation therapies that could be used to treat DOC patients. Both invasive and noninvasive brain stimulation is discussed. Significant behavioral improvements in prolonged DOCs under neuromodulation therapies are rare. The efficacy of various such therapies remains a matter of debate. Further clinical investigations of existing techniques in larger samples properly controlling for spontaneous recovery are needed, and new approaches are awaited.Treatment for disorders of consciousness （DOCs） is still a Gordian knot. Evidence-based guidelines on the treatment of DOC patients are not currently available, while neuromodulation techniques are seen as a potential treatment. Multiple neuromodulation therapies have been applied. This article reviews the most relevant studies in the literature in order to describe a clear picture of the current state of neuromodulation therapies that could be used to treat DOC patients. Both invasive and noninvasive brain stimulation is discussed. Significant behavioral improvements in prolonged DOCs under neuromodulation therapies are rare. The efficacy of various such therapies remains a matter of debate. Further clinical investigations of existing techniques in larger samples properly controlling for spontaneous recovery are needed, and new approaches are awaited.

关 键 词：Disorder of consciousness NEUROMODULATION Deep brain stimulation Spinal cord stimulation Repet-itive transcranial magnetic stimulation Transcranial directcurrent stimulation 

分 类 号：R741[医药卫生—神经病学与精神病学]