White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness  

作　　者：Xuehai Wu Jiaying Zhang Zaixu Cui Weijun Tang Chunhong Shao Jin Hu Jianhong Zhu Yao Zhao Lu Lu Gang Chen Georg Northoff Gaolang Gong Ying Mao Yong He 

机构地区：[1]Neurosurgical Department, Shanghai Huashan Hospital,Fudan University [2]State Key Laboratory of Cognitive Neuroscience and Learning, IDG/Mc Govern Institute for Brain Research,Beijing Normal University [3]Centre for Medical Image Computing, Department of Computer Science, University College London [4]Radiological Department, Shanghai Huashan Hospital, Fudan University [5]Psychiatry Department, Shanghai Huashan Hospital, Fudan University [6]Huajia Hospital,Shanghai [7]Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services [8]Institute of Mental Health Research, University of Ottawa

出　　处：《Neuroscience Bulletin》2018年第4期668-678,共11页神经科学通报（英文版）

基　　金：supported by the Natural Science Foundation of China (81571025);International Cooperation Project from Shanghai Science Foundation (18410711300);the National Science Foundation for Distinguished Young Scholars of China (81025013);National Basic Research Development Program (973 Program) of China (2012CB720700, 2010CB945500, 2012CB966300, and 2009CB941100);the National Natural Science Foundation of China (81322021);the Beijing Nova Program (Z121110002512032);the Project for National 985 Engineering of China (985III-YFX0102);the ‘‘Dawn Tracking’’ Program of Shanghai Education Commission (10GG01);the Shanghai Natural Science Foundation (08411952000 and 10ZR1405400);the National Natural Science Young Foundation in China (81201033);the grants of Shanghai Health Bureau (20114358);the National High-Technology Development Project (863 Project) of China (2015AA020501);the Program for New Century Excellent Talents in University of China (NCET-10-0356);the National Program for the Support of TopNotch Young Professionals;supported by the Michael Smith Foundation, the CRC, and the CIHR;supported by the China Scholarship Council

摘　　要：In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/ vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest （ROIs）, and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/ vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest （ROIs）, and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.

关 键 词：Disorder of consciousness White matter Diffusion tensor imaging Brain injury 

分 类 号：R741[医药卫生—神经病学与精神病学]