毛细胞黏液样星形细胞瘤3例临床病理观察  

Pilomyxoid astrocytoma:a clinicopathological analysis of three cases

作　　者：李俊芝[1] 王志强[2] 张巍[1] LI Jun-zhi;WANG Zhi-qiang;ZHANG Wei(Department of Pathology,the First Affilated Hospital of Xinjiang Medical University,Urumqi 830054,China;Department of Neurology,Xinjiang Armed Police Hospital,Urumqi 830091,China)

机构地区：[1]新疆医科大学第一附属医院病理科,乌鲁木齐830054 [2]武警新疆总队医院神经内科,乌鲁木齐830091

出　　处：《诊断病理学杂志》2018年第7期511-514,共4页Chinese Journal of Diagnostic Pathology

基　　金：新疆维吾尔自治区自然科学基金(2017D01C315)

摘　　要：目的探讨毛细胞黏液样星形细胞瘤(PMA)临床病理学特点及鉴别诊断。方法收集3例毛细胞黏液样星形细胞瘤,分析其临床特点,观察其病理组织学形态、免疫表型特征,并复习相关文献。结果 3例均为女童,年龄分别为26个月、22个月及7个月。病变分别位于鞍区视神经、三脑室和视交叉,形态符合毛细胞黏液样星形细胞瘤。免疫组化:瘤细胞GFAP、S-100、vimentin和olig-2不同程度(+),Ki-67<10%。结论毛细胞黏液样星形细胞瘤是一种罕见的中枢神经系统原发性肿瘤,为毛细胞型星形细胞瘤的一个亚型。该病发病率很低,发病年龄较小,多见于<4岁的儿童,预后差于毛细胞型星形细胞瘤。Objective To study the clinieopathologic features and differential diagnosis of pilomyxoid astrocytoma.Methods The clinical,morphology and immunophenolypic features were analyzed in 3 cases of pilomyxoid astrocytoma,with review of literature. Results Three cases of pilomyxoid astrocytoma were girls,aged 26 months,22 months and 7 months,repectively; the tumors located in the saddle area of optic nerve lesions. The pathologic changes of the tumor were accorded with that of pilomyxoid astrocytoma. Immunohistochemical staining showed that tumor cells expressed GFAP,S-100,Vim,olig-2 in different levels; tumor cell proliferation index（ Ki-67） was〈 10%. Conclusion Pilomyxoid astrocytoma is a rare primary central nervous system tumor,a variant of pilocytic astrocytoma. It is a very low incidence of the disease; age of onset is more commonly less than 4 years,with poorer prognosis than that of pilocytic astrocytoma.

关 键 词：毛细胞黏液样星形细胞瘤 鉴别诊断 预后 

分 类 号：R739.4[医药卫生—肿瘤]