结外间变性大细胞性淋巴瘤8例临床病理分析  

Extranodal anaplastic large cell lymphoma:a clinicopathological analysis of eight cases

作　　者：唐雪峰 王亚丽 孔莹琴 郭乔楠 TANG Xue-fen;WANG Ya-li;KONG Ying-qin;GUO Qiao-nan(Department of Pathology,Xinqiao Hospital,Army Medical University,Chongqin9 400037,Chin)

机构地区：[1]陆军军医大学新桥医院病理科,重庆400037

出　　处：《诊断病理学杂志》2018年第7期525-529,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨结外间变性大细胞淋巴瘤(ALCL)的临床病理学特征及诊断。方法对8例结外ALCL进行临床资料总结、组织学观察和免疫组化染色、EBER原位杂交检测,并进行相关文献复习。结果 8例中男女各4例,年龄15~86岁,平均年龄53岁。病变均位于淋巴结外,包括鼻腔、皮肤、十二指肠、骨、软组织和扁桃体。组织学显示2例细胞排列较疏松,1例为梭形细胞,3例缺乏间变性,仅3例可见Hallmark细胞。8例均可见围血管现象。8例肿瘤细胞CD30均弥漫强(+),4例ALK-P80(+)。随访时间7~52个月,7例生存。结论结外ALCL少见,形态学不典型,相应部位鉴别诊断多,诊断较困难,需加深对其认识。Objective To investigate the clinicopathological features and diagnosis of extranodal anaplastic large cell lymphoma（ ALCL）. Methods Eight cases of extranodal ALCL were retrospectively analyzed by clinical data,morphological features,immunohistochemical staining and EBV detection. The literatue was also reviewed. Results The patients of this series were 4 males and 4 females. The ages ranged from 15 to 86 years and mean ages was 53 years. All the cases were extranodal location including nasal cavity,skin,duodenum,bone,soft tisseue and tonsil. Histologically,tumor cells of 2 cases showed low density and 1 case showed spindle shaped. The tumor cells of 3 cases showed absence of anaplasia. Hallmark cells were observed only in 3 cases. Angiocentricity was found in all the cases. All the cases were strongly positve for CD30. Four cases were positive for ALK-P80. Follow-up period was 7 to 52 months and 7 patients were alive. Conclusion Extranodal ALCL is rare. It is difficult to make a diagnosis for laking of classic histological features.Deeper understanding of its clinicopathological features should be necessary.

关 键 词：间变性大细胞淋巴瘤 结外 诊断 

分 类 号：R733[医药卫生—肿瘤]