乙型肝炎病毒感染与非霍奇金淋巴瘤发病的相关性研究  

Study on the correlation between hepatitis B virus infection and the incidence of non-Hodgkin's lymphoma

作　　者：潘静[1] PAN Jing(No.1 Department of Infectious Diseases,Xiaogan Hospital of Wuhan University of Science and Technology,Xiaogan 432100,China)

机构地区：[1]武汉科技大学附属孝感医院感染一科,湖北孝感432100

出　　处：《中国现代医生》2018年第21期9-11,15,共4页China Modern Doctor

摘　　要：目的探讨乙型肝炎病毒感染与非霍奇金淋巴瘤发病的相关性。方法随机选取2009年2月~2017年8月在我院接受诊疗的640例非霍奇金淋巴瘤患者和640例肺癌患者作为研究对象,640例非霍奇金淋巴瘤患者为观察组,640例肺癌患者为对照组;比较两组患者乙型肝炎标志物阳性率,比较B细胞型、T细胞型两种病理亚型的非霍奇金淋巴瘤患者乙型肝炎标志物阳性率。结果观察组患者的HBs Ag阳性率为17.19%,对照组为12.19%,观察组高于对照组,两组之间差异具有统计学意义(χ~2=13.32,P<0.05);观察组HBs Ag阴性率为18.44%,对照组为21.25%,两组间差异无统计学意义(χ~2=3.31,P>0.05);两组患者单抗体、双抗体及三抗体阳性率组间比较差异均无统计学意义(P>0.05)。观察组B细胞型NHL患者HBs Ag阳性率19.51%,T细胞型NHL患者HBs Ag阳性率13.89%,B细胞型的HBs Ag阳性率高于T细胞型的,两组之间差异有统计学意义(χ~2=5.02,P<0.05);B细胞型NHL患者HBs Ag阴性率为18.05%,T细胞型NHL患者HBs Ag阴性率为22.78%,两组间差异无统计学意义(χ~2=3.41,P>0.05);两组患者单抗体、双抗体及三抗体阳性率组间比较差异均无统计学意义(P>0.05)。结论非霍奇金淋巴瘤患者的乙型肝炎病毒感染率高于肺癌患者,两者存在相关性。乙型肝炎病毒感染和B细胞型NHL的发生也存在相关性。Objective To explore the clinical correlation between hepatitis B virus infection and the incidence of non- Hodgkin＇s lymphoma. Methods 640 patients with non-Hodgkin＇s lymphoma and 640 patients with lung cancer who were treated in our hospital from February 2009 to August 2017 were randomly selected as the study subjects. 640 pa- tients with non-Hodgkin＇s lymphoma were assigned to the observation group, and 640 patients with lung cancer were assigned to the control group; the positive rate of hepatitis B markers was compared between the two groups. The posi- tive rate of hepatitis B markers in non-Hodgkin＇s lymphoma patients with two pathological subtypes： B cell type and T cell type. Results The positive rate of HBsAg was 17.19% in the observation group and 12.19% in the control group. The observation group was higher than the control group, and the difference between the two groups was statistically significant（x2=13.32, P〈0.05）; the negative rate of HBsAg was 18.44% in the observation group and 21.25% in the control group. There was no statistically significant difference between the two groups（x2=3.31, P〉0.05）; there was no statistically significant difference in the positive rates of single antibody, double antibody and tri-antibody between the two groups（P〉0.05）. In the observation group, the positive rate of HBsAg in B-cell type NHL patients was 19.51%, and the positive rate of HBsAg in T-cell type NHL patients was 13.89%. The positive rate of B-cell type HBsAg was higher than that of T-cell type. The difference between the two groups was statistically significant（x2=5.02, P〈0.05）; the negative rate of HBsAg in B-cell type NHL patients was 18.05%, and the negative rate of HBsAg in T-cell type NHL patients was 22.78%. The difference between the two groups was not statistically significant（x2=3.41,P〉0.05）; there was no statistically significant difference in the positive rates of single antibody, double antibody and tri-antibody between the two groups（PM）.05）. Co

关 键 词：肝炎病毒乙型 非霍奇金淋巴瘤 感染 相关性 

分 类 号：R733.1[医药卫生—肿瘤] R512.62[医药卫生—临床医学]