Altered leukocyte gene expression after traumatic spinal cord injury:clinical implications  

作　　者：Paige E.Herman Ona Bloom 

机构地区：[1]The Feinstein Institute for Medical Research,Northwell Health [2]Departments of Physical Medicine and Rehabilitation,Molecular Medicine,Donald and Barbara Zucker School of Medicine at Hofstra Northwell

出　　处：《Neural Regeneration Research》2018年第9期1524-1529,共6页中国神经再生研究（英文版）

基　　金：supported by grants from the Craig H.Neilsen Foundation;the NY State Empire Clinical Research Program;the NY State Spinal Cord Injury Research Board(grants to OB)

摘　　要：In addition to changes in motor and sensory function, individuals with spinal cord injury （SCI） experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardio- vascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to im- prove immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genom- ics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI.In addition to changes in motor and sensory function, individuals with spinal cord injury （SCI） experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardio- vascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to im- prove immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genom- ics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI.

关 键 词：traumatic spinal cord injury INFLAMMATION immune cells functional genomics gene expression AUTOIMMUNITY MICROARRAY chronic spinal cord injury 

分 类 号：R651.2[医药卫生—外科学]