神经甾体在精神分裂症发病与治疗中作用的研究进展  

Progress in neurosteroids related to the pathogenesis and treatment of schizophrenia

作　　者：曹婷 李娜娜[1,2] 蔡骅琳[1,2] CAO Ting;LI Nana;CAI Huali(Department of Pharmacy,the Second Xiangya Hospital of Central South University,Changsha 410011,Hu- nan,China;Institute of Clinical Pharmacy,Central South University,Changsha 410011,Hunan,China)

机构地区：[1]中南大学湘雅二医院药学部 [2]中南大学临床药学研究所

出　　处：《中国临床药理学与治疗学》2018年第6期709-714,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金青年基金资助项目(81401113);湖南省自然科学基金青年基金资助项目(2017JJ3444)

摘　　要：研究表明神经甾体代谢可能与精神分裂症的发病和治疗密切相关,本文将从神经甾体的生物合成、其在精神分裂症中的变化、作用机制及辅助治疗、性别差异等方面分别阐述,探讨相关神经甾体在精神分裂症发病与治疗中的潜在作用,旨在为神经甾体辅助治疗精神分裂症提供理论依据,为其治疗干预和监测提供创新性靶点。The latest researches have shown that the metabolism of neurosteroids is probably involved in the pathogenesis of schizophrenia and associated with relevant treatment. This review will focus on the relationship between neurosteroids and schizophrenia,mainly from these perspectives： biosynthesis of neurosteroids, alternation of neurosteroids,mechanism of action and its auxiliary role in schizophrenia,gender differences etc. so as to provide theoretical references for applying neurosteroids in adjuvant treatment of schizophrenia.

关 键 词：神经甾体 生物合成 作用机制 辅助治疗 精神分裂症 性别差异 

分 类 号：R749.3[医药卫生—神经病学与精神病学]