CT引导下^(125)I放射性粒子植入治疗头颈部浅表恶性肿瘤近期疗效观察  

Observation on short-term effect of CT-guided ^(125)I radioactive particles implantation in treatment of head and neck superficial malignant tumors

作　　者：杨海波[1] 黄定强[1] 李琛[2] YANG Haibo;HUANG Dingqiang;LI Chen(Department of Otolaryngology Head and Neck Surgery;Department ofIntervention Radiology,Ya＇an People＇s Hospital,Ya＇an 625000,China)

机构地区：[1]雅安市人民医院耳鼻咽喉头颈外科,四川雅安625000 [2]雅安市人民医院介入科,四川雅安625000

出　　处：《中国介入影像与治疗学》2018年第8期457-460,共4页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的探讨CT引导下^(125)I放射性粒子治疗头颈部浅表恶性肿瘤的近期疗效。方法回顾性分析28例头颈部浅表恶性肿瘤患者的资料,所有患者均接受CT引导下^(125)I放射粒子植入治疗,并具有完整的术后随访复查资料。观察患者术后并发症发生情况,并评价术后放射性皮肤损伤程度。基于术后6个月影像学检查图像,评价治疗效果,计算客观缓解率(ORR)及疾病控制率(DCR)。通过绘制生存曲线,获得患者术后总生存期及无进展生存期,并计算术后1年生存率及无进展生存率。结果术后6个月ORR为92.86%(26/28),DCR为100%(28/28)。术后平均随访(25.6±8.9)个月。28例患者中位总生存期为26.98个月[95%CI(22.55,31.39)],中位无进展生存期为16.93个月[95%CI(14.47,19.39)];术后1年总生存率为96.43%(27/28),无进展生存率为82.14%(23/28)。96.43%(27/28)患者术后放射性皮肤损伤为0～Ⅱ度,仅3.57%(1/28)患者为Ⅲ度。术后均未出现血管栓塞、破裂等并发症。结论 CT引导下^(125)I放射性粒子治疗头颈浅表恶性肿瘤近期疗效确切,且安全性较高。Objective To explore the short-term effect of CT-guided 125Ⅰ radioactive particles implantation in treatment of superficial malignant tumors of head and neck.Methods Data of 28 patients with superficial malignant tumors of head and neck were retrospectively analyzed.All patients underwent CT-guided 125Ⅰ radioactive particles implantation and had complete postoperative follow-up information.The postoperative complications were observed,and the degree of radiation skin injuries was evaluated.Objective remission rate（ORR）and disease control rate（DCR）were calculated based on the imaging examination of CT 6 months after implantation.The total survival period and no progression survival period were obtained by drawing the survival curve,and the 1-year survival rate and no progression survival rate were calculated.Results Six months after implantation,ORR was 92.86%（26/28）,and DCR was 100%（28/28）.The average follow-up time was（25.6±8.9）months.The median overall survival of 28 patients was 26.98 months（95%CI[22.55,31.39]）.The median progression-free survival was 16.93 months（95% CI[14.47,19.39]）.One year after implantation,the total survival rate was 96.43%（27/28）,and the progression-free survival rate was 82.14%（23/28）.Radiation-induced skin injuries were found in96.43%（27/28）patients with 0—Ⅱdegrees,and in 3.57%（1/28）patient withⅢ degree.There was no complication such as vascular embolization or rupture occurred after implantation.Conclusion CT-guided 125Ⅰ radioactive particles implantation are effective and safe for treating superficial malignant tumors of head and neck in near term.

关 键 词：头颈部肿瘤 恶性 125Ⅰ放射性粒子植入 CT引导 治疗结果 

分 类 号：R739.81[医药卫生—肿瘤] R459.9[医药卫生—临床医学]