中老年人群高敏C反应蛋白变化与视网膜血管直径的关系：开滦研究  

Relationship between the changes of high-sensitivity C-reactive protein and retinal vessel diameter in the middle-aged and elderly：the Kailuan Study

作　　者：刘欣欣[1] 卢爱东[1] 王亚星 魏文斌 陈朔华 吴寿岭[4] Liu Xinxin;Lu Aidong;Wang Yaxing;Wei Wenbin;Chen Shuohua;Wu Shouling(The Department of Ophthalmology,Department of Cardiology,Kailuan General Hospital,Tangshan 063000,Chin;Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,Chin;Kailuan Employees Health Care Center,Tangshan 063000,China)

机构地区：[1]开滦总医院眼科,河北省唐山市063000 [2]首都医科大学附属北京同仁医院北京同仁眼科中心,100730 [3]开滦员工健康保健中心,河北省唐山市063000 [4]开滦总医院心内科,河北省唐山市063000

出　　处：《中华实验眼科杂志》2018年第8期629-635,共7页Chinese Journal Of Experimental Ophthalmology

摘　　要：目的探讨中老年人群高敏C反应蛋白（hsCRP）变化与视网膜血管直径的关系。方法采用横断面研究方法，研究人群来源于开滦研究（临床试验注册号：ChiCTR-TNC-1100 1489）2012—2013年间查体人群（年龄≥40岁），对所有人群进行心脑血管及流行病学检查，其中有3 447人有可分析的彩色眼底照相检查结果，应用软件分析视网膜血管直径。取hsCRP 1%～99%分位3 363人，最后纳入统计分析3 363人，其中男1 880人，女1 483人；平均年龄（56.69±10.10）岁。采用Spearman秩相关系数评价hsCRP与视网膜中央动脉直径（CRAE）、视网膜中央静脉直径（CRVE）和动静脉比（AVR）之间的相关性。多因素线性回归分析进一步分析hsCRP与眼底血管直径各参数之间的关联。结果研究对象的hsCRP中位数值为1.10（0.50，2.21）mmo/L，CRAE平均值为（174.16±24.36）μm，CRVE平均值为（282.70±26.32）μm，AVR为0.62±0.09。Spearman相关分析可见hsCRP与CRVE呈正相关（r＝0.052，P＝0.003），与AVR呈负相关（r＝－0.052，P＝0.002）。将非正态变量hsCRP转化为连续变量lghsCRP，分别与CRAE、CRVE和AVR进行多因素线性回归分析，在逐步校正了多种因素后，结果显示lghsCRP与CRVE（β＝3.428）、AVR（β＝－0.006）的关联有统计学意义（P〈0.05），在将性别分层计算后仍可见在男女人群中lghsCRP均是CRVE的危险因素。结论CRVE随着hsCRP表达水平的升高而增宽，AVR随着hsCRP表达水平的升高而减小。眼底血管直径的改变或许可与hsCRP一起作为标志物用来预测心脑血管疾病的发生。ObjectiveTo investigate the relationship between high-sensitivity C-reactive protein （hsCRP） and retinal vascular diameter.MethodsThis study was a cross-sectional study, the population was from the Kailuan study （clinical trial research registration NO.： ChiCTR-TNC-1100 1489） in 2012—2013 （age≥40 years）. All the people was checked by cardiovascular and epidemiological examination, of which 3 447 people had an analytical results of fundus color photography.The retinal vascular diameter was analyzed by software.Take the value of hsCRP 1% to 99% points and 3 363 people were finally included in the statistical analysis.The mean age of 3 363 people （male 1 880, female 1 483） was 56.69±10.10 years old.The correlation between hsCRP and central retinal artery equivalent（CRAE）, central retinal vein equivalent （CRVE）, arteriovenous ratio（AVR） were evaluated by Spearman correlation coefficient.Multivariate linear regression analysis was used to futher analyze the association between hsCRP and retinal fundus diameter parameters.ResultsThe median value of hsCRP was 1.10（0.50, 2.21）mmo/L, CRAE was （174.16±24.36）μm, CRVE was （282.70±26.32）μm, AVR was 0.62±0.09.Spearman correlation analysis showed that hsCRP was positively correlated with CRVE （r=0.052, P=0.003） and negatively correlated with AVR （r=-0.052, P=0.002）. The non-normal variables hsCRP were transformed into continuous variables lghsCRP, and CRAE, CRVE and AVR were used for multivariate linear regression analysis.After a number of factors were gradually corrected, the results showed that association between lghsCRP and CRVE （β=3.428） or AVR （β=-0.006） was statistically significant （P〈0.05）. LghsCRP was a risk factor for CRVE both in men and women after the calculation of gender stratification.ConclusionsCRVE increased and AVR decreased with the increase of hsCRP.The changes of retinal vascular diameter may be associated with hsCRP as a marker to predict cardiovascular and cerebrovascular disea

关 键 词：视网膜中央动脉直径 视网膜中央静脉直径 高敏C反应蛋白 

分 类 号：R774.1[医药卫生—眼科]