新生血管性眼病发病相关细胞因子研究进展  

Research progress of pathological relevant cytokines of neovascular eye diseases

作　　者：韩梦雨(综述) 王志军(审校)[2] 金明(审校)[2] HanMengyu;Wang Zhijun;Jin Ming(Beijing University of Chinese Medicine,Beijing 100029,China;Department of Ophthalmology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学,100029 [2]中日友好医院眼科,100029

出　　处：《中华实验眼科杂志》2018年第8期636-642,共7页Chinese Journal Of Experimental Ophthalmology

摘　　要：新生血管性眼病呈现高度复杂性和难治性，是近年来国内外临床眼科医生遇到的治疗较为棘手的一大类疾病。新生血管形成的具体机制尚未完全明确，目前已知其是多因子、多途径共同参与的复杂过程。眼内正常血管生成是局部微环境处于生理状态下，促血管生成因子与抑制血管生成因子之间动态平衡的结果。在缺血、缺氧及炎症等病理因素诱导下，这些细胞因子间的动态平衡被打破，引发眼内新生血管的生成。尽管目前的研究表明，包括血管内皮生长因子（VEGF）、色素上皮衍生因子（PEDF）等在内的多种细胞因子与眼内新生血管的形成密切相关，但更为重要的是阐明众多细胞因子参与眼内新生血管形成的分子机制，从而明确新生血管性眼病的发病机制。本文就VEGF、胰岛素样生长因子-1（IGF-1）、血管生成素-2（Ang-2）、基质细胞衍生因子-1（SDF-1）、PEDF等与新生血管性眼病发病相关细胞因子的研究进展进行综述。Neovascular eye diseases, with highly complicated and refractory, are one group of the most difficult problems for domestic and overseas clinical oculists in recent years.Angiogenesis is a complex process participating with multiple factors and various ways, and its exact pathogenesis is unclear yet.Ocular neovascularization is the dynamic balance result between proangiogenic factors and antiangiogenic factors provided that intraocular microenvironment be under a physiological condition.Some pathological factors including ischemia, hypoxia and inflammation destroy the dynamic balance between cytokines leading to neovascularization.Currently studies indicated that numerous cytokines containing vascular endothelial growth factor （VEGF） and pigment epithelium derived factor （PEDF） are closely linked to ocular neovascularization, while it is more crucial to elucidate the molecular mechanism of numerous cytokines involved in ocular neovascularization, which can recognize the pathogenesis of neovascular eye disease more clearly.Research progress of pathological relevant cytokines of neovascular eye diseases, including VEGF, insulin-like growth factor 1 （IGF-1）, angiogenin-2 （Ang-2）, stromal cell derived factor 1 （SDF-1） and PEDF were reviewed in this paper.

关 键 词：眼内新生血管 细胞因子 血管内皮生长因子 基质细胞衍生因子-1 血管生成素-2 胰 岛素样生长因子-1 色素上皮衍生因子 

分 类 号：R77[医药卫生—眼科]