卵巢癌组织中IL-6与SOCS1阳性表达及其意义  

EXPRESSION OF INTERLEUKIN-6 AND SUPPRESSOR OF CYTOKINE SIGNALING-1 IN OVARIAN CANCER TISSUE AND ITS CLINICAL SIGNIFICANCE

作　　者：王然然[1] 丁朝霞[1] 杨红娟[1] 赵鑫[1] 陈爱平[1] WANG Ranran;DING Zhaoxia;YANG Hongjuan;ZHAO Xin;CHEN Aiping(Department of Gynecology,The Affiliated Hospital of Qingdao University,Qingdao 266003,Chin)

机构地区：[1]青岛大学附属医院妇科,山东青岛266003

出　　处：《青岛大学学报（医学版）》2018年第4期443-445,449,共4页Journal of Qingdao University(Medical Sciences)

摘　　要：目的探讨白细胞介素6(IL-6)和细胞因子信号转导抑制因子1(SOCS1)在卵巢癌组织中的阳性表达及临床意义。方法采用免疫组化二步法检测不同卵巢组织中IL-6和SOCS1的阳性表达,分析两者的表达及其与卵巢癌临床病理参数间的关系。结果卵巢癌组织中IL-6和SOCS1的阳性表达率高于正常卵巢和良性卵巢肿瘤组织(χ~2=6.094~28.983,P<0.05)。卵巢癌组织中IL-6的阳性表达与肿瘤的组织学分级、FIGO分期、腹水有关(χ~2=8.451~14.872,P<0.05),与病理类型、年龄、淋巴结转移无关(P>0.05)。SOCS1阳性表达与肿瘤的组织学分级有关(χ~2=6.137,P<0.05),与病理类型、FIGO分期、腹水、年龄、淋巴结转移无关(P>0.05)。卵巢癌组织中IL-6与SOCS1的表达呈正相关(r=0.297,P<0.05)。结论 IL-6和SOCS1在卵巢癌中高表达,与卵巢癌的发生发展相关。Objective To investigate the expression of interleukin-6（IL-6）and suppressor of cytokine signaling-1（SOCS1）in ovarian cancer tissue and its clinical significance. Methods Immunohistochemistry was used to measure the expression of IL-6 and SOCS1 in different ovarian tissue samples,and its association with clinicopathological parameters of ovarian cancer was analyzed. Results Compared with normal ovarian tissue samples and benign ovarian tumor samples,ovarian cancer tissue samples had significantly higher expression of IL-6 and SOCS1（χ~2=6.094-28.983,P〈0.05）.In the ovarian cancer tissue samples,the expression of IL-6 was associated with histological grade of tumor,International Federation of Gynecology and Obstetrics（FIGO）stage,and ascites（χ~2=8.451-14.872,P〈0.05）,but it was not associated with pathological type,age,or lymph node metastasis（P〉0.05）.The expression of SOCS1 was associated with histological grade of tumor（χ~2=6.137,P〈0.05）,but it was not associated with pathological type,FIGO stage,ascites,age,or lymph node metastasis（P〉0.05）.In the ovarian cancer tissue samples,the expression of IL-6 was positively correlated with that of SOCS1,the difference is significant（r=0.297,P〈0.05）.Conclusion IL-6 and SOCS1 are highly expressed in ovarian cancer tissue,which is associated with the development and progression of ovarian cancer.

关 键 词：卵巢肿瘤 白细胞介素6 细胞因子信号转导蛋白抑制因子 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]